Utility and limitations of serum creatinine as a measure of renal function in experimental renal ischemia-reperfusion injury

Michael P. O'Donnell, Melissa Burne, Frank Daniels, Hamid Rabb

Research output: Contribution to journalArticle

Abstract

Background. Ischemia-reperfusion injury (IRI) is the major cause of delayed graft function in renal allografts. The present study was performed to investigate the validity of serum creatinine (SCr) level as an indicator of postischemic renal dysfunction in mice. Methods. Renal IRI or sham surgery was induced in C57BL/6 mice, and SCr level and inulin clearance (Cin) were measured between 24 hr and 7 days after ischemia. Results. Cin in IRI mice was reduced 75% at 72 hr after ischemia in association with a nearly threefold increase in SCr level. Cin in IRI mice did not recover between 72 hr and 7 days after ischemia, even though SCr level at 7 days was not different between control and IRI mice. In IRI mice, SCr level measured at 24, 48, and 72 hr after ischemia correlated inversely with Cin measured at 72 hr, but not 7 days, after ischemia. Conclusions. SCr level in the early postischemic period (24-72 hr) seems to be a valid indicator of early postischemic renal dysfunction, and that renal function remains markedly depressed at 7 days despite suggestion from the SCr value that renal function is improving.

Original languageEnglish (US)
Pages (from-to)1841-1844
Number of pages4
JournalTransplantation
Volume73
Issue number11
DOIs
StatePublished - Jun 15 2002

ASJC Scopus subject areas

  • Transplantation

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