Uterine serous carcinoma: Molecular features, clinical management, and new and future therapies

Elizabeth K. Lee, Amanda N. Fader, Alessandro D. Santin, Joyce F. Liu

Research output: Contribution to journalReview articlepeer-review

Abstract

Uterine serous carcinoma (USC) is an aggressive subtype of endometrial cancer. Multimodality treatment with surgery, radiotherapy, and chemotherapy is commonly used, given its propensity for extrauterine spread, distant recurrences, and poor prognosis. However, the use of molecularly-based therapy is expanding. Here, we review key molecular features of USC, discuss current management, and assess the landscape of novel therapies and combinations.

Original languageEnglish (US)
Pages (from-to)322-332
Number of pages11
JournalGynecologic oncology
Volume160
Issue number1
DOIs
StatePublished - Jan 2021

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology

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