TY - JOUR
T1 - Usual dietary isoflavone intake and reproductive function across the menstrual cycle
AU - Filiberto, Amanda C.
AU - Mumford, Sunni L.
AU - Pollack, Anna Z.
AU - Zhang, Cuilin
AU - Yeung, Edwina H.
AU - Schliep, Karen C.
AU - Perkins, Neil J.
AU - Wactawski-Wende, Jean
AU - Schisterman, Enrique F.
N1 - Funding Information:
Supported by the Intramural Research Program at the Eunice Kennedy Shriver National Institute of Child Health and Human Development , National Institute of Health.
PY - 2013/12
Y1 - 2013/12
N2 - Objective To assess the association of total isoflavone intake with ovulatory function, including sporadic anovulation in healthy premenopausal women. Design Prospective cohort study. Setting University. Patient(s) Participants included 259 healthy regularly menstruating women aged 18-44 years. Intervention(s) None. Main Outcome Measure(s) Serum concentrations of E 2, free E2, P, LH, FSH, and SHBG and sporadic anovulation in healthy premenopausal women. Result(s) Isoflavone intake was not associated with E2, free E2, P, LH, and FSH concentrations. Consumption in the highest quartile (Q4: 1.6-78.8 mg/d) was significantly associated with greater SHBG concentrations (β = 0.09; 95% confidence interval [CI] 0.02-0.16), compared with the first quartile (Q1: 0.0-0.3 mg/d). Conclusion(s) Isoflavone intake was not associated with sporadic anovulation (Q4 vs. Q1: odds ratio 0.87, 95% CI 0.32-1.66). Dietary isoflavone intake among young premenopausal women was not related to sex hormone concentrations or anovulation, but was associated with minimally increased SHBG concentrations. These results suggest potential endocrine effects with no subsequent effects on ovulation, easing concerns regarding their impacts on fertility.
AB - Objective To assess the association of total isoflavone intake with ovulatory function, including sporadic anovulation in healthy premenopausal women. Design Prospective cohort study. Setting University. Patient(s) Participants included 259 healthy regularly menstruating women aged 18-44 years. Intervention(s) None. Main Outcome Measure(s) Serum concentrations of E 2, free E2, P, LH, FSH, and SHBG and sporadic anovulation in healthy premenopausal women. Result(s) Isoflavone intake was not associated with E2, free E2, P, LH, and FSH concentrations. Consumption in the highest quartile (Q4: 1.6-78.8 mg/d) was significantly associated with greater SHBG concentrations (β = 0.09; 95% confidence interval [CI] 0.02-0.16), compared with the first quartile (Q1: 0.0-0.3 mg/d). Conclusion(s) Isoflavone intake was not associated with sporadic anovulation (Q4 vs. Q1: odds ratio 0.87, 95% CI 0.32-1.66). Dietary isoflavone intake among young premenopausal women was not related to sex hormone concentrations or anovulation, but was associated with minimally increased SHBG concentrations. These results suggest potential endocrine effects with no subsequent effects on ovulation, easing concerns regarding their impacts on fertility.
KW - Isoflavone
KW - anovulation
KW - nutrition
KW - sex hormones
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U2 - 10.1016/j.fertnstert.2013.08.002
DO - 10.1016/j.fertnstert.2013.08.002
M3 - Article
C2 - 23998910
AN - SCOPUS:84888437665
SN - 0015-0282
VL - 100
SP - 1727
EP - 1734
JO - Fertility and sterility
JF - Fertility and sterility
IS - 6
ER -