Usual dietary isoflavone intake and reproductive function across the menstrual cycle

Amanda C. Filiberto, Sunni L. Mumford, Anna Z. Pollack, Cuilin Zhang, Edwina H. Yeung, Karen C. Schliep, Neil J. Perkins, Jean Wactawski-Wende, Enrique F. Schisterman

Research output: Contribution to journalArticlepeer-review

Abstract

Objective To assess the association of total isoflavone intake with ovulatory function, including sporadic anovulation in healthy premenopausal women. Design Prospective cohort study. Setting University. Patient(s) Participants included 259 healthy regularly menstruating women aged 18-44 years. Intervention(s) None. Main Outcome Measure(s) Serum concentrations of E 2, free E2, P, LH, FSH, and SHBG and sporadic anovulation in healthy premenopausal women. Result(s) Isoflavone intake was not associated with E2, free E2, P, LH, and FSH concentrations. Consumption in the highest quartile (Q4: 1.6-78.8 mg/d) was significantly associated with greater SHBG concentrations (β = 0.09; 95% confidence interval [CI] 0.02-0.16), compared with the first quartile (Q1: 0.0-0.3 mg/d). Conclusion(s) Isoflavone intake was not associated with sporadic anovulation (Q4 vs. Q1: odds ratio 0.87, 95% CI 0.32-1.66). Dietary isoflavone intake among young premenopausal women was not related to sex hormone concentrations or anovulation, but was associated with minimally increased SHBG concentrations. These results suggest potential endocrine effects with no subsequent effects on ovulation, easing concerns regarding their impacts on fertility.

Original languageEnglish (US)
Pages (from-to)1727-1734
Number of pages8
JournalFertility and Sterility
Volume100
Issue number6
DOIs
StatePublished - Dec 2013
Externally publishedYes

Keywords

  • anovulation
  • Isoflavone
  • nutrition
  • sex hormones

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Reproductive Medicine
  • Medicine(all)

Fingerprint Dive into the research topics of 'Usual dietary isoflavone intake and reproductive function across the menstrual cycle'. Together they form a unique fingerprint.

Cite this