Usual blood pressure, peripheral arterial disease, and vascular risk

Cohort study of 4.2 million adults

Connor A. Emdin, Simon G. Anderson, Thomas Callender, Nathalie Conrad, Gholamreza Salimi-Khorshidi, Hamid Mohseni, Mark Woodward, Kazem Rahimi

Research output: Contribution to journalArticle

Abstract

OBJECTIVES: To determine the subgroup specific associations between usual blood pressure and risk of peripheral arterial disease, and to examine the relation between peripheral arterial disease and a range of other types of vascular disease in a large contemporary cohort. DESIGN: Cohort study. SETTING: Linked electronic health records from 1990 to 2013 in the United Kingdom. PARTICIPANTS: 4 222 459 people aged 30-90 years, registered at a primary care practice for at least one year and with a blood pressure measurement. MAIN OUTCOME MEASURES: Time to first diagnosis of new onset peripheral arterial disease and time to first diagnosis of 12 different vascular events. RESULTS: A 20 mm Hg higher than usual systolic blood pressure was associated with a 63% higher risk of peripheral arterial disease (hazard ratio 1.63, 95% confidence interval 1.59 to 1.66). The strength of the association declined with increasing age and body mass index (P

Original languageEnglish (US)
Article numberh4865
JournalBMJ (Online)
Volume351
DOIs
StatePublished - Sep 29 2015

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Peripheral Arterial Disease
Blood Vessels
Cohort Studies
Blood Pressure
Electronic Health Records
Vascular Diseases
Primary Health Care
Body Mass Index
Confidence Intervals

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Emdin, C. A., Anderson, S. G., Callender, T., Conrad, N., Salimi-Khorshidi, G., Mohseni, H., ... Rahimi, K. (2015). Usual blood pressure, peripheral arterial disease, and vascular risk: Cohort study of 4.2 million adults. BMJ (Online), 351, [h4865]. https://doi.org/10.1136/bmj.h4865

Usual blood pressure, peripheral arterial disease, and vascular risk : Cohort study of 4.2 million adults. / Emdin, Connor A.; Anderson, Simon G.; Callender, Thomas; Conrad, Nathalie; Salimi-Khorshidi, Gholamreza; Mohseni, Hamid; Woodward, Mark; Rahimi, Kazem.

In: BMJ (Online), Vol. 351, h4865, 29.09.2015.

Research output: Contribution to journalArticle

Emdin, CA, Anderson, SG, Callender, T, Conrad, N, Salimi-Khorshidi, G, Mohseni, H, Woodward, M & Rahimi, K 2015, 'Usual blood pressure, peripheral arterial disease, and vascular risk: Cohort study of 4.2 million adults', BMJ (Online), vol. 351, h4865. https://doi.org/10.1136/bmj.h4865
Emdin CA, Anderson SG, Callender T, Conrad N, Salimi-Khorshidi G, Mohseni H et al. Usual blood pressure, peripheral arterial disease, and vascular risk: Cohort study of 4.2 million adults. BMJ (Online). 2015 Sep 29;351. h4865. https://doi.org/10.1136/bmj.h4865
Emdin, Connor A. ; Anderson, Simon G. ; Callender, Thomas ; Conrad, Nathalie ; Salimi-Khorshidi, Gholamreza ; Mohseni, Hamid ; Woodward, Mark ; Rahimi, Kazem. / Usual blood pressure, peripheral arterial disease, and vascular risk : Cohort study of 4.2 million adults. In: BMJ (Online). 2015 ; Vol. 351.
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