Using the deadly μ-conotoxins as probes of voltage-gated sodium channels

Ronald A. Li; Gordon F. Tomaselli

doi:10.1016/j.toxicon.2004.03.028

Using the deadly μ-conotoxins as probes of voltage-gated sodium channels

Ronald A. Li, Gordon F. Tomaselli

School of Medicine

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

μ-Conotoxins (μ-CTX) are potent Na channel inhibitory peptides isolated from the venom of the predatory marine snail Conus geographus. μ-CTXs exert their biological action by physically occluding the ion-conducting pore of voltage-gated Na (Na_v) channels with a 1:1 stoichiometry in an all-or-none fashion. This article reviews our current knowledge of the mechanism of μ-CTX and the associated structural and functional insights into its molecular target - Na_v channels.

Original language	English (US)
Pages (from-to)	117-122
Number of pages	6
Journal	Toxicon
Volume	44
Issue number	2
DOIs	https://doi.org/10.1016/j.toxicon.2004.03.028
State	Published - Aug 2004

Keywords

μ-Conotoxin
Na channel
Pore

ASJC Scopus subject areas

Toxicology

Access to Document

10.1016/j.toxicon.2004.03.028

Cite this

@article{c31b65e3ee4549acba29559bbe12ccb0,

title = "Using the deadly μ-conotoxins as probes of voltage-gated sodium channels",

abstract = "μ-Conotoxins (μ-CTX) are potent Na channel inhibitory peptides isolated from the venom of the predatory marine snail Conus geographus. μ-CTXs exert their biological action by physically occluding the ion-conducting pore of voltage-gated Na (Nav) channels with a 1:1 stoichiometry in an all-or-none fashion. This article reviews our current knowledge of the mechanism of μ-CTX and the associated structural and functional insights into its molecular target - Nav channels.",

keywords = "μ-Conotoxin, Na channel, Pore",

author = "Li, {Ronald A.} and Tomaselli, {Gordon F.}",

year = "2004",

month = aug,

doi = "10.1016/j.toxicon.2004.03.028",

language = "English (US)",

volume = "44",

pages = "117--122",

journal = "Toxicon",

issn = "0041-0101",

publisher = "Elsevier Limited",

number = "2",

}

TY - JOUR

T1 - Using the deadly μ-conotoxins as probes of voltage-gated sodium channels

AU - Li, Ronald A.

AU - Tomaselli, Gordon F.

PY - 2004/8

Y1 - 2004/8

N2 - μ-Conotoxins (μ-CTX) are potent Na channel inhibitory peptides isolated from the venom of the predatory marine snail Conus geographus. μ-CTXs exert their biological action by physically occluding the ion-conducting pore of voltage-gated Na (Nav) channels with a 1:1 stoichiometry in an all-or-none fashion. This article reviews our current knowledge of the mechanism of μ-CTX and the associated structural and functional insights into its molecular target - Nav channels.

AB - μ-Conotoxins (μ-CTX) are potent Na channel inhibitory peptides isolated from the venom of the predatory marine snail Conus geographus. μ-CTXs exert their biological action by physically occluding the ion-conducting pore of voltage-gated Na (Nav) channels with a 1:1 stoichiometry in an all-or-none fashion. This article reviews our current knowledge of the mechanism of μ-CTX and the associated structural and functional insights into its molecular target - Nav channels.

KW - μ-Conotoxin

KW - Na channel

KW - Pore

UR - http://www.scopus.com/inward/record.url?scp=3042792925&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=3042792925&partnerID=8YFLogxK

U2 - 10.1016/j.toxicon.2004.03.028

DO - 10.1016/j.toxicon.2004.03.028

M3 - Article

C2 - 15246758

AN - SCOPUS:3042792925

SN - 0041-0101

VL - 44

SP - 117

EP - 122

JO - Toxicon

JF - Toxicon

IS - 2

ER -

Using the deadly μ-conotoxins as probes of voltage-gated sodium channels

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this