Abstract
μ-Conotoxins (μ-CTX) are potent Na channel inhibitory peptides isolated from the venom of the predatory marine snail Conus geographus. μ-CTXs exert their biological action by physically occluding the ion-conducting pore of voltage-gated Na (Nav) channels with a 1:1 stoichiometry in an all-or-none fashion. This article reviews our current knowledge of the mechanism of μ-CTX and the associated structural and functional insights into its molecular target - Nav channels.
Original language | English (US) |
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Pages (from-to) | 117-122 |
Number of pages | 6 |
Journal | Toxicon |
Volume | 44 |
Issue number | 2 |
DOIs | |
State | Published - Aug 2004 |
Keywords
- μ-Conotoxin
- Na channel
- Pore
ASJC Scopus subject areas
- Toxicology