Using tagged MRI to quantify the 3D deformation of a cadaver brain in response to angular acceleration

A. K. Knutsen, W. T. Wang, J. E. McEntee, J. Zhuo, R. Gullapalli, J. L. Prince, P. V. Bayly, J. B. Butman, D. L. Pham

Research output: Chapter in Book/Report/Conference proceedingChapter


A quantitative three-dimensional (3D) description of the deformation of brain tissue during acceleration of the skull is necessary to provide understanding of the underlying mechanisms of traumatic brain injury. Tagged magnetic resonance imaging (MRI) allows for the noninvasive measurement of the deformation of biological tissue. In this study, tagged MRI with harmonic phase (HARP) analysis was used to quantify the 3D deformation during angular acceleration of a gelatin phantom and the head of a human cadaver specimen. Two-dimensional results from the gelatin phantom showed good agreement with previously published results. Two-dimensional strains in the cadaver brain were lower in magnitude than previously reported results from a similar experiment in the live human brain. Strains on the inferior–superior axis were measured and shown to be of similar magnitude to the strain components in the plane formed by the anterior–posterior and left–right axes. Future studies will involve the acquisition of 3D deformation fields in live humans and additional cadaver specimens.

Original languageEnglish (US)
Title of host publicationComputational Biomechanics for Medicine
Subtitle of host publicationModels, Algorithms and Implementation
PublisherSpringer New York
Number of pages15
ISBN (Electronic)9781461463511
ISBN (Print)9781461463504
StatePublished - Jan 1 2013
Externally publishedYes

ASJC Scopus subject areas

  • Engineering(all)


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