Using serial analysis of gene expression to identify tumor markers and antigens

Research output: Contribution to journalArticlepeer-review

Abstract

Tumor markers and antigens are normally highly expressed in malignant tissue, but not in the surrounding normal tissue. Serial analysis of gene expression (SAGE) is a technology that counts mRNA transcripts and can be used to find those genes most highly induced in malignant tissues. SAGE produces a comprehensive profile of gene expression and can be used to search for tumor biomarkers in a limited number of samples. Public sources of SAGE data, in particular through the Cancer Genome Anatomy Project, increase the value of this technology by making a large source of information on many tumors and normal tissues available for comparison. Although the perfect tumor-specific gene does not exist, the differences in gene expression between tumor and normal can be exploited for therapeutic or diagnostic purposes.

Original languageEnglish (US)
Pages (from-to)41-48
Number of pages8
JournalDisease Markers
Volume17
Issue number2
DOIs
StatePublished - 2001

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Clinical Biochemistry
  • Biochemistry, medical

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