TY - JOUR
T1 - Using overlap volume histogram and IMRT plan data to guide and automate VMAT planning
T2 - A head-and-neck case study
AU - Wu, Binbin
AU - Pang, Dalong
AU - Simari, Patricio
AU - Taylor, Russell
AU - Sanguineti, Giuseppe
AU - McNutt, Todd
PY - 2013/2
Y1 - 2013/2
N2 - Purpose: To investigate whether an overlap volume histogram (OVH)-driven planning application using an intensity-modulated radiation therapy (IMRT) database can guide and automate volumetric-modulated arc therapy (VMAT) planning for head-and-neck cancer. Methods: Based on comparable head-and-neck dosimetric results between planner-generated VMAT and IMRT plans, an inhouse developed, OVH-driven automated planning application containing a database of prior clinical head-and-neck IMRT plans is built into Pinnacle3 SmartArc for VMAT planning. Double-arc VMAT plans of four oropharynx, four nasopharynx, and four larynx patients are generated and compared with corresponding clinical IMRT plans. Results: Each VMAT plan is automatically generated in two optimization rounds, while the average number of optimization rounds in generating a clinical IMRT plan is 43. In VMAT plans, statistical superiority (p < 0.01) in sparing of the cord+4 mm, brainstem, brachial plexus, larynx, and inner ear is observed with a slight degradation in low-dose-level planning target volume (PTV) coverage. On average, D0.1 cc to the cord+4 mm, brainstem and brachial plexus is reduced by 3.7, 4.9, and 1.6 Gy, respectively; V(50 Gy) to the larynx is reduced by 5.3%; mean dose to the inner ear is reduced by 4.4 Gy; V95 of low-dose-level PTV coverage is reduced by 0.3% with p = 0.25. Conclusions: IMRT-data-driven VMAT planning offers a potential method for generating VMAT plans that are comparable to IMRT plans in terms of dosimetric quality.
AB - Purpose: To investigate whether an overlap volume histogram (OVH)-driven planning application using an intensity-modulated radiation therapy (IMRT) database can guide and automate volumetric-modulated arc therapy (VMAT) planning for head-and-neck cancer. Methods: Based on comparable head-and-neck dosimetric results between planner-generated VMAT and IMRT plans, an inhouse developed, OVH-driven automated planning application containing a database of prior clinical head-and-neck IMRT plans is built into Pinnacle3 SmartArc for VMAT planning. Double-arc VMAT plans of four oropharynx, four nasopharynx, and four larynx patients are generated and compared with corresponding clinical IMRT plans. Results: Each VMAT plan is automatically generated in two optimization rounds, while the average number of optimization rounds in generating a clinical IMRT plan is 43. In VMAT plans, statistical superiority (p < 0.01) in sparing of the cord+4 mm, brainstem, brachial plexus, larynx, and inner ear is observed with a slight degradation in low-dose-level planning target volume (PTV) coverage. On average, D0.1 cc to the cord+4 mm, brainstem and brachial plexus is reduced by 3.7, 4.9, and 1.6 Gy, respectively; V(50 Gy) to the larynx is reduced by 5.3%; mean dose to the inner ear is reduced by 4.4 Gy; V95 of low-dose-level PTV coverage is reduced by 0.3% with p = 0.25. Conclusions: IMRT-data-driven VMAT planning offers a potential method for generating VMAT plans that are comparable to IMRT plans in terms of dosimetric quality.
KW - DVH
KW - IMRT database
KW - OVH
KW - VMAT
KW - head-and-neck
UR - http://www.scopus.com/inward/record.url?scp=84873604523&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84873604523&partnerID=8YFLogxK
U2 - 10.1118/1.4788671
DO - 10.1118/1.4788671
M3 - Article
C2 - 23387737
AN - SCOPUS:84873604523
VL - 40
JO - Medical Physics
JF - Medical Physics
SN - 0094-2405
IS - 2
M1 - 021714
ER -