Using optics to measure biological forces and mechanics

Research output: Contribution to journalReview articlepeer-review

37 Scopus citations


Spanning all size levels, regulating biological forces and transport are fundamental life processes. Used by various investigators over the last dozen years, optical techniques offer unique advantages for studying biological forces. The most mature of these techniques, optical tweezers, or the single-beam optical trap, is commercially available and is used by numerous investigators. Although technical innovations have improved the versatility of optical tweezers, simple optical tweezers continue to provide insights into cell biology. Two new, promising optical technologies, laser-tracking microrheology and the optical stretcher, allow mechanical measurements that are not possible with optical tweezers. Here, I review these various optical technologies and their roles in understanding mechanical forces in cell biology.

Original languageEnglish (US)
Pages (from-to)757-763
Number of pages7
Issue number11
StatePublished - 2001


  • Laser tweezers
  • Laser-tracking microrheology
  • Optical forces
  • Optical strecher
  • Optical tweezers
  • Single-beam optical trap

ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology


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