Using metastasis suppressor proteins to dissect interactions among cancer cells and their microenvironment

Jennifer Taylor, Jonathan Hickson, Tamara Lotan, Diane Seiko Yamada, Carrie Rinker-Schaeffer

Research output: Contribution to journalArticle

Abstract

Cancer metastasis is a complex, dynamic process that begins with dissemination of cells from the primary tumor and culminates in the formation of clinically detectable, overt metastases at one or more discontinuous secondary sites. Evidence from in vivo video microscopy as well as PCR and immunohistochemical studies suggest that cancer cell dissemination is an early event in tumor progression and that cells may persist in a potentially dormant state for a prolonged period. Similarly, the mechanisms by which these disseminated cells initiate growth and complete the process of metastatic colonization remain largely unknown. Understanding signal transduction pathways regulating this final step of metastasis is therefore critical for successful clinical management. While genetic mutations or epigenetic changes may be required for a cell or group of cells to separate and survive distant from the primary tumor, the microenvironment within secondary tissues plays a substantial role in influencing whether disseminated cells survive and proliferate. Our work is focused on using metastasis suppressor proteins to gain insight into why the majority of disseminated cells, which should be fully malignant, do not proliferate immediately at secondary sites. The translational goal of this work is to identify targets for inhibiting metastatic growth and prolonging disease-free survival.

Original languageEnglish (US)
Pages (from-to)67-73
Number of pages7
JournalCancer and Metastasis Reviews
Volume27
Issue number1
DOIs
StatePublished - Mar 2008
Externally publishedYes

Fingerprint

Tumor Suppressor Proteins
Cellular Microenvironment
Neoplasms
Neoplasm Metastasis
Video Microscopy
Tumor Microenvironment
Growth
Epigenomics
Disease-Free Survival
Signal Transduction
Polymerase Chain Reaction
Mutation

Keywords

  • Dormancy
  • Metastasis
  • Metastasis suppressor
  • MKK4/JNKK1
  • SAPK

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Using metastasis suppressor proteins to dissect interactions among cancer cells and their microenvironment. / Taylor, Jennifer; Hickson, Jonathan; Lotan, Tamara; Yamada, Diane Seiko; Rinker-Schaeffer, Carrie.

In: Cancer and Metastasis Reviews, Vol. 27, No. 1, 03.2008, p. 67-73.

Research output: Contribution to journalArticle

Taylor, Jennifer ; Hickson, Jonathan ; Lotan, Tamara ; Yamada, Diane Seiko ; Rinker-Schaeffer, Carrie. / Using metastasis suppressor proteins to dissect interactions among cancer cells and their microenvironment. In: Cancer and Metastasis Reviews. 2008 ; Vol. 27, No. 1. pp. 67-73.
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