Using intravoxel incoherent motion MR imaging to study the renal pathophysiological process of contrast-induced acute kidney injury in rats: Comparison with conventional DWI and arterial spin labelling

Long Liang, Wen bo Chen, Kannie W.Y. Chan, Yu guo Li, Bin Zhang, Chang hong Liang, Guan shu Liu, Shui xing Zhang

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: To investigate the potential of intravoxel incoherent motion (IVIM) to assess the renal pathophysiological process in contrast-induced acute kidney injury (CIAKI). Methods: Twenty-seven rats were induced with CIAKI model, six rats were imaged longitudinally at 24 h prior to and 30 min, 12, 24, 48, 72 and 96 h after administration; three rats were randomly chosen from the rest for serum creatinine and histological studies. D, f, D* and ADC were calculated from IVIM, and renal blood flow (RBF) was obtained from arterial spin labelling (ASL). Results: A progressive reduction in D and ADC was observed in cortex (CO) by 3.07 and 8.62 % at 30 min, and by 25.77 and 28.16 % at 48 h, respectively. A similar change in outer medulla (OM) and inner medulla (IM) was observed at a later time point (12–72 h). D values were strongly correlated with ADC (r = 0.885). As perfusion measurement, a significant decrease was shown for f in 12–48 h and an increase in 72–96 h. A slightly different trend was found for D*, which was decreased by 26.02, 21.78 and 10.19 % in CO, OM and IM, respectively, at 30 min. f and D* were strongly correlated with RBF in the cortex (r = 0.768, r = 0.67), but not in the medulla. Conclusions: IVIM is an effective imaging tool for monitoring progress in renal pathophysiology undergoing CIAKI. Key Points: • IVIM analysis permits separate quantification of diffusion and perfusion. • IVIM can provide useful biomarkers ifor changes in renal pathophysiology. • IVIM can be useful for monitoring progress in renal pathophysiology undergoing CIAKI.

Original languageEnglish (US)
Pages (from-to)1597-1605
Number of pages9
JournalEuropean radiology
Volume26
Issue number6
DOIs
StatePublished - Jun 1 2016

Keywords

  • Apparent diffusion coefficient
  • Arterial spin labelling
  • Contrast-induced acute kidney injury
  • Diffusion-weighted imaging
  • Intravoxel incoherent motion

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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