Using human induced pluripotent stem cells for modeling schizophrenia, a psychiatric disorder

Tarja A. Juopperi; Hongjun Song; Guo Li Ming

doi:10.1016/j.ddmod.2012.05.002

Using human induced pluripotent stem cells for modeling schizophrenia, a psychiatric disorder

Tarja A. Juopperi, Hongjun Song, Guo Li Ming

School of Medicine

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

There are inherent difficulties in developing well-defined experimental systems to study complex psychiatric disorders, such as schizophrenia. Advances have been made utilizing animal models; however, limitations in their ability to fully recapitulate the human disease exist. Induced pluripotent stem cells (iPSCs) derived from patients have the potential to revolutionize disease modeling for schizophrenia research and to provide a valuable resource for identification of crucial molecular pathways, biomarkers and for therapeutic drug screening.

Original language	English (US)
Journal	Drug Discovery Today: Disease Models
Volume	9
Issue number	4
DOIs	https://doi.org/10.1016/j.ddmod.2012.05.002
State	Published - Dec 2012

ASJC Scopus subject areas

Drug Discovery
Molecular Medicine

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10.1016/j.ddmod.2012.05.002

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abstract = "There are inherent difficulties in developing well-defined experimental systems to study complex psychiatric disorders, such as schizophrenia. Advances have been made utilizing animal models; however, limitations in their ability to fully recapitulate the human disease exist. Induced pluripotent stem cells (iPSCs) derived from patients have the potential to revolutionize disease modeling for schizophrenia research and to provide a valuable resource for identification of crucial molecular pathways, biomarkers and for therapeutic drug screening.",

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Using human induced pluripotent stem cells for modeling schizophrenia, a psychiatric disorder

Abstract

ASJC Scopus subject areas

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