Using genetic variation to study immunomodulation

Stephen Chanock, James G. Taylor VI

Research output: Contribution to journalReview articlepeer-review

Abstract

The generation of a draft sequence of a human genome has led to the identification of millions of common variants, known as single nucleotide polymorphisms, which constitute a resource for studying complex diseases. Currently, high-density maps of variants in candidate genes, chromosomal regions or the entire genome should encourage investigation of determinants of human immune response, using quantitative analysis. Ultimately, this approach should identify novel targets for therapeutic intervention.

Original languageEnglish (US)
Pages (from-to)463-469
Number of pages7
JournalCurrent Opinion in Pharmacology
Volume2
Issue number4
DOIs
StatePublished - Aug 1 2002

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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