Using dipyridamole-thallium imaging to reduce cardiac risk in aortic reconstruction

Curtis A. Erickson, Richard E. Carballo, Julie A. Freischlag, Gary R. Seabrook, Michael M. Farooq, Robert A. Cambria, Jonathan B. Towne

Research output: Contribution to journalArticle

Abstract

Cardiac morbidity and mortality remain the major operative risk following aortic reconstruction (AR) performed for aneurysmal and occlusive disease. We reviewed the preoperative cardiac evaluation and outcome in 209 patients who had AR between 1987 and 1992. Dipyridamole-thallium stress test (DTST) was performed in 147 (70.3%) patients. Fifty-six of these patients had a normal DTST and only 1 (1.8%) had a perioperative myocardial infarction (MI). Forty- six patients had a fixed defect on their DTST and 3 (6.5%) had perioperative MI. Forty-five patients had reversible defects on their DTST and 2 (4.4%) had perioperative MI with 1 cardiac death. Following DTST, 29 coronary catheterizations were performed. Ten catheterizations were normal or had minimal one-vessel coronary artery disease with an associated postoperative death in 1 patient due to cardiac dysrhythmia. Nineteen patients had abnormal coronary angiography, 1 of whom had a perioperative myocardial infarction and 5 of whom underwent coronary artery revascularization (CABG) (3) or percutaneous transluminal angioplasty (2) prior to AR without subsequent cardiac events. Forty-three (20.6%) had either no cardiac symptoms (40) or prior CABG (3) precluding invasive cardiac evaluation. There was one fatal perioperative myocardial infarction (2.3%), resulting in a cardiac mortality of 2.3% in this group. The remaining 19 patients who did not have a DTST (9.1%) had coronary angiography based on evidence of significant cardiac disease resulting in one CABG and one percutaneous transluminal angioplasty. There was one (5.3%) perioperative myocardial infarction in this group and no cardiac deaths. Thirty-day mortality was 3.8%, perioperative MI rate was 3.8%, and perioperative cardiac mortality was 1.0%. During the follow-up period (median, 18 months; range, 1-89), there were 19 deaths (10%) and the 5-year cumulative survival was 76%. Conclusion: Selective use of DTST can direct further evaluation, intervention, and subsequent perioperative care. This algorithm has enabled us to perform AR even in patients with defined perfusion abnormalities with acceptable morbidity. The true sensitivity, specificity, and predictive value of DTST can only be determined by a prospective trial.

Original languageEnglish (US)
Pages (from-to)422-428
Number of pages7
JournalJournal of Surgical Research
Volume60
Issue number2
DOIs
StatePublished - Feb 1 1996
Externally publishedYes

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Dipyridamole
Thallium
Exercise Test
Myocardial Infarction
Mortality
Coronary Angiography
Angioplasty
Catheterization
Morbidity
Perioperative Care
Cardiac Arrhythmias
Coronary Artery Disease
Heart Diseases
Coronary Vessels
Perfusion
Sensitivity and Specificity
Survival

ASJC Scopus subject areas

  • Surgery

Cite this

Erickson, C. A., Carballo, R. E., Freischlag, J. A., Seabrook, G. R., Farooq, M. M., Cambria, R. A., & Towne, J. B. (1996). Using dipyridamole-thallium imaging to reduce cardiac risk in aortic reconstruction. Journal of Surgical Research, 60(2), 422-428. https://doi.org/10.1006/jsre.1996.0069

Using dipyridamole-thallium imaging to reduce cardiac risk in aortic reconstruction. / Erickson, Curtis A.; Carballo, Richard E.; Freischlag, Julie A.; Seabrook, Gary R.; Farooq, Michael M.; Cambria, Robert A.; Towne, Jonathan B.

In: Journal of Surgical Research, Vol. 60, No. 2, 01.02.1996, p. 422-428.

Research output: Contribution to journalArticle

Erickson, CA, Carballo, RE, Freischlag, JA, Seabrook, GR, Farooq, MM, Cambria, RA & Towne, JB 1996, 'Using dipyridamole-thallium imaging to reduce cardiac risk in aortic reconstruction', Journal of Surgical Research, vol. 60, no. 2, pp. 422-428. https://doi.org/10.1006/jsre.1996.0069
Erickson CA, Carballo RE, Freischlag JA, Seabrook GR, Farooq MM, Cambria RA et al. Using dipyridamole-thallium imaging to reduce cardiac risk in aortic reconstruction. Journal of Surgical Research. 1996 Feb 1;60(2):422-428. https://doi.org/10.1006/jsre.1996.0069
Erickson, Curtis A. ; Carballo, Richard E. ; Freischlag, Julie A. ; Seabrook, Gary R. ; Farooq, Michael M. ; Cambria, Robert A. ; Towne, Jonathan B. / Using dipyridamole-thallium imaging to reduce cardiac risk in aortic reconstruction. In: Journal of Surgical Research. 1996 ; Vol. 60, No. 2. pp. 422-428.
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abstract = "Cardiac morbidity and mortality remain the major operative risk following aortic reconstruction (AR) performed for aneurysmal and occlusive disease. We reviewed the preoperative cardiac evaluation and outcome in 209 patients who had AR between 1987 and 1992. Dipyridamole-thallium stress test (DTST) was performed in 147 (70.3{\%}) patients. Fifty-six of these patients had a normal DTST and only 1 (1.8{\%}) had a perioperative myocardial infarction (MI). Forty- six patients had a fixed defect on their DTST and 3 (6.5{\%}) had perioperative MI. Forty-five patients had reversible defects on their DTST and 2 (4.4{\%}) had perioperative MI with 1 cardiac death. Following DTST, 29 coronary catheterizations were performed. Ten catheterizations were normal or had minimal one-vessel coronary artery disease with an associated postoperative death in 1 patient due to cardiac dysrhythmia. Nineteen patients had abnormal coronary angiography, 1 of whom had a perioperative myocardial infarction and 5 of whom underwent coronary artery revascularization (CABG) (3) or percutaneous transluminal angioplasty (2) prior to AR without subsequent cardiac events. Forty-three (20.6{\%}) had either no cardiac symptoms (40) or prior CABG (3) precluding invasive cardiac evaluation. There was one fatal perioperative myocardial infarction (2.3{\%}), resulting in a cardiac mortality of 2.3{\%} in this group. The remaining 19 patients who did not have a DTST (9.1{\%}) had coronary angiography based on evidence of significant cardiac disease resulting in one CABG and one percutaneous transluminal angioplasty. There was one (5.3{\%}) perioperative myocardial infarction in this group and no cardiac deaths. Thirty-day mortality was 3.8{\%}, perioperative MI rate was 3.8{\%}, and perioperative cardiac mortality was 1.0{\%}. During the follow-up period (median, 18 months; range, 1-89), there were 19 deaths (10{\%}) and the 5-year cumulative survival was 76{\%}. Conclusion: Selective use of DTST can direct further evaluation, intervention, and subsequent perioperative care. This algorithm has enabled us to perform AR even in patients with defined perfusion abnormalities with acceptable morbidity. The true sensitivity, specificity, and predictive value of DTST can only be determined by a prospective trial.",
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AU - Cambria, Robert A.

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N2 - Cardiac morbidity and mortality remain the major operative risk following aortic reconstruction (AR) performed for aneurysmal and occlusive disease. We reviewed the preoperative cardiac evaluation and outcome in 209 patients who had AR between 1987 and 1992. Dipyridamole-thallium stress test (DTST) was performed in 147 (70.3%) patients. Fifty-six of these patients had a normal DTST and only 1 (1.8%) had a perioperative myocardial infarction (MI). Forty- six patients had a fixed defect on their DTST and 3 (6.5%) had perioperative MI. Forty-five patients had reversible defects on their DTST and 2 (4.4%) had perioperative MI with 1 cardiac death. Following DTST, 29 coronary catheterizations were performed. Ten catheterizations were normal or had minimal one-vessel coronary artery disease with an associated postoperative death in 1 patient due to cardiac dysrhythmia. Nineteen patients had abnormal coronary angiography, 1 of whom had a perioperative myocardial infarction and 5 of whom underwent coronary artery revascularization (CABG) (3) or percutaneous transluminal angioplasty (2) prior to AR without subsequent cardiac events. Forty-three (20.6%) had either no cardiac symptoms (40) or prior CABG (3) precluding invasive cardiac evaluation. There was one fatal perioperative myocardial infarction (2.3%), resulting in a cardiac mortality of 2.3% in this group. The remaining 19 patients who did not have a DTST (9.1%) had coronary angiography based on evidence of significant cardiac disease resulting in one CABG and one percutaneous transluminal angioplasty. There was one (5.3%) perioperative myocardial infarction in this group and no cardiac deaths. Thirty-day mortality was 3.8%, perioperative MI rate was 3.8%, and perioperative cardiac mortality was 1.0%. During the follow-up period (median, 18 months; range, 1-89), there were 19 deaths (10%) and the 5-year cumulative survival was 76%. Conclusion: Selective use of DTST can direct further evaluation, intervention, and subsequent perioperative care. This algorithm has enabled us to perform AR even in patients with defined perfusion abnormalities with acceptable morbidity. The true sensitivity, specificity, and predictive value of DTST can only be determined by a prospective trial.

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