Using Big Data to Evaluate the Association between Periodontal Disease and Rheumatoid Arthritis

Michael A. Grasso, Angela C. Comer, Dana DiRenzo, Yelena Yesha, Naphtali D. Rishe

Research output: Contribution to journalArticle

Abstract

An association between periodontal disease and rheumatoid arthritis is believed to exist. Most investigations into a possible relationship have been case-control studies with relatively low sample sizes. The advent of very large clinical repositories has created new opportunities for data-driven research. We conducted a retrospective cohort study to measure the association between periodontal disease and rheumatoid arthritis in a population of 25 million patients. We demonstrated that subjects with periodontal disease were roughly 1.4 times more likely to have rheumatoid arthritis. These results compare favorably with those of previous studies on smaller cohorts. Additional work is needed to identify the mechanisms behind this association and to determine if aggressive treatment of periodontal disease can alter the course of rheumatoid arthritis.

Original languageEnglish (US)
Pages (from-to)589-593
Number of pages5
JournalAMIA ... Annual Symposium proceedings. AMIA Symposium
Volume2015
StatePublished - Jan 1 2015
Externally publishedYes

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Periodontal Diseases
Rheumatoid Arthritis
Sample Size
Case-Control Studies
Cohort Studies
Retrospective Studies
Research
Population
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Using Big Data to Evaluate the Association between Periodontal Disease and Rheumatoid Arthritis. / Grasso, Michael A.; Comer, Angela C.; DiRenzo, Dana; Yesha, Yelena; Rishe, Naphtali D.

In: AMIA ... Annual Symposium proceedings. AMIA Symposium, Vol. 2015, 01.01.2015, p. 589-593.

Research output: Contribution to journalArticle

Grasso, Michael A. ; Comer, Angela C. ; DiRenzo, Dana ; Yesha, Yelena ; Rishe, Naphtali D. / Using Big Data to Evaluate the Association between Periodontal Disease and Rheumatoid Arthritis. In: AMIA ... Annual Symposium proceedings. AMIA Symposium. 2015 ; Vol. 2015. pp. 589-593.
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