Using an MR imaging-guidewire as an intravascular local heating source: Toward thermal enhancement of vascular gene transfection

Bensheng Qiu, Christopher J. Yeung, Xiangyiog Du, Ergin Atalar, Xiaoming Yang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Heating can enhance gene transfection/expression. We developed a novel endovascular microwave heating source using an MR imaging-guidewire (MRIG) to deliver external microwave energy into the target vessels. We investigated (i) microwave power loss along differently-sized MRIGs; (ii) microwave power distribution around MRIGs; and (iii) temperature increases versus input microwave powers with MRIGs. Then, we evaluted, in vivo, the possibility of using the MR imaging/heating guidewire to generate high-resolution MR images and deliver the controlled therapuetic heat energy into the target vessel wall with histological confirmation. The results showed that the MRIG had no thermal damage to the vessel wall and can be used as an intravascular local heating device. This study has established the groundwork for further efficient management of cardiovascular atherosclerotic diseases using MRI-based vascular gene therapy.

Original languageEnglish (US)
Title of host publicationProceedings - International Symposium on Biomedical Imaging
PublisherIEEE Computer Society
Pages425-428
Number of pages4
Volume2002-January
ISBN (Print)078037584X
DOIs
StatePublished - 2002
EventIEEE International Symposium on Biomedical Imaging, ISBI 2002 - Washington, United States
Duration: Jul 7 2002Jul 10 2002

Other

OtherIEEE International Symposium on Biomedical Imaging, ISBI 2002
CountryUnited States
CityWashington
Period7/7/027/10/02

ASJC Scopus subject areas

  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

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    Qiu, B., Yeung, C. J., Du, X., Atalar, E., & Yang, X. (2002). Using an MR imaging-guidewire as an intravascular local heating source: Toward thermal enhancement of vascular gene transfection. In Proceedings - International Symposium on Biomedical Imaging (Vol. 2002-January, pp. 425-428). [1029285] IEEE Computer Society. https://doi.org/10.1109/ISBI.2002.1029285