Abstract
A reliable computer method was developed for straightforward, rapid determination of whole brain and cerebrospinal fluid (CSF) volumes from a set of contiguous transaxial magnetic resonance images. The semiautomatic algorithm used a threshold-guided edge follower. Subtraction of proton-weighted from T2-weighted images was used to highlight CSF. Phantom studies were used for validity assessment. Interrater and intrarater reliability and correlation with manual measurement were excellent. Percent CSF and brain volumes were determined for small groups of Alzheimer's disease, HIV seropositive, obsessive-compulsive disorder, and schizophrenic patients as well as for young and elderly normal controls.
Original language | English (US) |
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Pages (from-to) | 61-68 |
Number of pages | 8 |
Journal | Psychiatry Research: Neuroimaging |
Volume | 40 |
Issue number | 1 |
DOIs | |
State | Published - May 1991 |
Externally published | Yes |
Keywords
- Brain volume
- cerebrospinal fluid percentage
- computer methods
- magnetic resonance imaging
ASJC Scopus subject areas
- Neuroscience (miscellaneous)
- Radiology Nuclear Medicine and imaging
- Psychiatry and Mental health