User-friendly method for rapid brain and CSF volume calculation using transaxial MRI images

Gordon J. Harris, Edward H. Rhew, Thomas Noga, Godfrey D. Pearlson

    Research output: Contribution to journalArticlepeer-review


    A reliable computer method was developed for straightforward, rapid determination of whole brain and cerebrospinal fluid (CSF) volumes from a set of contiguous transaxial magnetic resonance images. The semiautomatic algorithm used a threshold-guided edge follower. Subtraction of proton-weighted from T2-weighted images was used to highlight CSF. Phantom studies were used for validity assessment. Interrater and intrarater reliability and correlation with manual measurement were excellent. Percent CSF and brain volumes were determined for small groups of Alzheimer's disease, HIV seropositive, obsessive-compulsive disorder, and schizophrenic patients as well as for young and elderly normal controls.

    Original languageEnglish (US)
    Pages (from-to)61-68
    Number of pages8
    JournalPsychiatry Research: Neuroimaging
    Issue number1
    StatePublished - May 1991


    • Brain volume
    • cerebrospinal fluid percentage
    • computer methods
    • magnetic resonance imaging

    ASJC Scopus subject areas

    • Neuroscience (miscellaneous)
    • Radiology Nuclear Medicine and imaging
    • Psychiatry and Mental health


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