Usefulness of soluble and surface-bound P-selectin in detecting heightened platelet activity in patients with congestive heart failure

Christopher M. O'Connor, Paul A. Gurbel, Victor L. Serebruany

Research output: Contribution to journalArticlepeer-review

Abstract

P-selectin is an important marker of platelet activation and may be up- regulated in patients with congestive heart failure (CHF). We sought to prospectively compare simultaneously determined platelet and soluble P- selectin in patients with CHF and in healthy controls. Matched soluble levels by enzyme-linked immmunosorbent assay, and platelet-bound expression by whole blood flow cytometry of P-selectin were measured in 22 patients with CHF and compared with 14 healthy controls. Twelve patients were aspirin free and 10 patients were taking aspirin (81 to 500 mg/day). Patients with CHF had significantly elevated soluble P-selectin (186.6 ± 82.7 ng/ml, p = 0.017) and more than twofold increased expression of platelet-bound P-selectin (9.58 ± 7.16% of positive platelets, p = 0.021) compared with the P-selectin profile (102.6 ± 29.0 ng/ml of plasma, and 4.06 ± 1.21% of positive platelets, respectively) in controls. Aspirin therapy did not affect the P- selectin profile in patients with CHF. Despite antecedent aspirin therapy and interindividual variability of the P-selectin profile, soluble and platelet P-selectin were elevated in most patients with severe CHF, suggesting persistent platelet activation.

Original languageEnglish (US)
Pages (from-to)1345-1349
Number of pages5
JournalAmerican Journal of Cardiology
Volume83
Issue number9
DOIs
StatePublished - May 1 1999

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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