TY - JOUR
T1 - Usefulness of Plasma Brain Natriuretic Peptide Concentration for Predicting Subsequent Left Ventricular Remodeling After Coronary Angioplasty in Patients With Acute Myocardial Infarction
AU - Hirayama, Atsushi
AU - Kusuoka, Hideo
AU - Yamamoto, Hiroyoshi
AU - Sakata, Yasushi
AU - Asakura, Masanori
AU - Higuchi, Yoshiharu
AU - Mizuno, Hiroya
AU - Kashiwase, Kazunori
AU - Ueda, Yasunori
AU - Okuyama, Yuji
AU - Hori, Masatsugu
AU - Kodama, Kazuhisa
PY - 2006/8/15
Y1 - 2006/8/15
N2 - To determine the relation between plasma brain natriuretic peptide (BNP) and remodeling in terms of infarct-related artery (IRA) patency, 106 patients with a first anterior wall acute myocardial infarction with a patent IRA at 1 month were studied. The IRA reoccluded at 6 months in 17 patients (reoccluded IRA) and was patent in 89 patients (patent IRA). The 2 groups did not differ with respect to clinical characteristics, hemodynamic variables, and left ventricular function at 1 month, except for left ventricular end-diastolic and systolic volumes, which were significantly greater in the reoccluded IRA group. Plasma BNP concentration in the reoccluded IRA group (336 ± 288 pg/ml) was significantly higher than that in the patent IRA group (116 ± 106 pg/ml) at 1 month. BNP concentration decreased significantly at 6 months in the 2 groups (reoccluded IRA vs patent IRA 152 ± 162 vs 44 ± 58 pg/ml, p <0.05). The increase in left ventricular volume from 1 to 6 months was significantly correlated with plasma BNP concentration at 1 month in the patent IRA group (r = 0.314, p <0.01) and the reoccluded group (r = 0.634, p <0.01). Linear regression analysis showed that the correlation between the 2 parameters in the 2 groups was similar. Based on stepwise multivariate linear regression analysis, only plasma BNP concentration was significantly correlated with the increase in left ventricular volume from 1 to 6 months in the 2 groups. In conclusion, these results suggest that plasma BNP concentration predicts left ventricular dilation independently of IRA patency.
AB - To determine the relation between plasma brain natriuretic peptide (BNP) and remodeling in terms of infarct-related artery (IRA) patency, 106 patients with a first anterior wall acute myocardial infarction with a patent IRA at 1 month were studied. The IRA reoccluded at 6 months in 17 patients (reoccluded IRA) and was patent in 89 patients (patent IRA). The 2 groups did not differ with respect to clinical characteristics, hemodynamic variables, and left ventricular function at 1 month, except for left ventricular end-diastolic and systolic volumes, which were significantly greater in the reoccluded IRA group. Plasma BNP concentration in the reoccluded IRA group (336 ± 288 pg/ml) was significantly higher than that in the patent IRA group (116 ± 106 pg/ml) at 1 month. BNP concentration decreased significantly at 6 months in the 2 groups (reoccluded IRA vs patent IRA 152 ± 162 vs 44 ± 58 pg/ml, p <0.05). The increase in left ventricular volume from 1 to 6 months was significantly correlated with plasma BNP concentration at 1 month in the patent IRA group (r = 0.314, p <0.01) and the reoccluded group (r = 0.634, p <0.01). Linear regression analysis showed that the correlation between the 2 parameters in the 2 groups was similar. Based on stepwise multivariate linear regression analysis, only plasma BNP concentration was significantly correlated with the increase in left ventricular volume from 1 to 6 months in the 2 groups. In conclusion, these results suggest that plasma BNP concentration predicts left ventricular dilation independently of IRA patency.
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U2 - 10.1016/j.amjcard.2006.03.022
DO - 10.1016/j.amjcard.2006.03.022
M3 - Article
C2 - 16893696
AN - SCOPUS:33746715540
SN - 0002-9149
VL - 98
SP - 453
EP - 457
JO - American Journal of Cardiology
JF - American Journal of Cardiology
IS - 4
ER -