Usefulness of Maintaining a Normal Electrocardiogram Over Time for Predicting Cardiovascular Health

Elsayed Z. Soliman, Zhu Ming Zhang, Lin Y. Chen, Larisa G. Tereshchenko, Dan Arking, Alvaro Alonso

Research output: Contribution to journalArticle

Abstract

We hypothesized that maintaining a normal electrocardiogram (ECG) status over time is associated with low cardiovascular (CV) disease in a dose-response fashion and subsequently could be used to monitor programs aimed at promoting CV health. This analysis included 4,856 CV disease-free participants from the Atherosclerosis Risk in Communities study who had a normal ECG at baseline (1987 to 1989) and complete electrocardiographic data in subsequent 3 visits (1990 to 1992, 1993 to 1995, and 1996 to 1998). Participants were classified based on maintaining their normal ECG status during these 4 visits into “maintained,” “not maintained,” or “inconsistent” normal ECG status as defined by the Minnesota ECG classification. CV disease events (coronary heart disease, heart failure, and stroke) were adjudicated from Atherosclerosis Risk in Communities visit-4 through 2010. Over a median follow-up of 13.2 years, 885 CV disease events occurred. The incidence rate of CV disease events was lowest among study participants who maintained a normal ECG status, followed by those with an inconsistent pattern, and then those who did not maintain their normal ECG status (trend p value <0.001). Similarly, the greater the number of visits with a normal ECG status, the lower was the incidence rate of CV disease events (trend p value <0.001). Maintaining (vs not maintaining) a normal ECG status was associated with a lower risk of CV disease, which was lower than that observed in those with inconsistent normal ECG pattern (trend p value <0.01). In conclusion, maintaining a normal ECG status over time is associated with low risk of CV disease in a dose-response fashion, suggesting its potential use as a monitoring tool for programs promoting CV health.

Original languageEnglish (US)
Pages (from-to)249-255
Number of pages7
JournalAmerican Journal of Cardiology
Volume119
Issue number2
DOIs
StatePublished - Jan 15 2017

Fingerprint

Electrocardiography
Cardiovascular Diseases
Health
Atherosclerosis
Incidence
Coronary Disease
Heart Failure
Stroke

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Usefulness of Maintaining a Normal Electrocardiogram Over Time for Predicting Cardiovascular Health. / Soliman, Elsayed Z.; Zhang, Zhu Ming; Chen, Lin Y.; Tereshchenko, Larisa G.; Arking, Dan; Alonso, Alvaro.

In: American Journal of Cardiology, Vol. 119, No. 2, 15.01.2017, p. 249-255.

Research output: Contribution to journalArticle

Soliman, Elsayed Z. ; Zhang, Zhu Ming ; Chen, Lin Y. ; Tereshchenko, Larisa G. ; Arking, Dan ; Alonso, Alvaro. / Usefulness of Maintaining a Normal Electrocardiogram Over Time for Predicting Cardiovascular Health. In: American Journal of Cardiology. 2017 ; Vol. 119, No. 2. pp. 249-255.
@article{8403df767d7547a2a1bdea55d1c059e7,
title = "Usefulness of Maintaining a Normal Electrocardiogram Over Time for Predicting Cardiovascular Health",
abstract = "We hypothesized that maintaining a normal electrocardiogram (ECG) status over time is associated with low cardiovascular (CV) disease in a dose-response fashion and subsequently could be used to monitor programs aimed at promoting CV health. This analysis included 4,856 CV disease-free participants from the Atherosclerosis Risk in Communities study who had a normal ECG at baseline (1987 to 1989) and complete electrocardiographic data in subsequent 3 visits (1990 to 1992, 1993 to 1995, and 1996 to 1998). Participants were classified based on maintaining their normal ECG status during these 4 visits into “maintained,” “not maintained,” or “inconsistent” normal ECG status as defined by the Minnesota ECG classification. CV disease events (coronary heart disease, heart failure, and stroke) were adjudicated from Atherosclerosis Risk in Communities visit-4 through 2010. Over a median follow-up of 13.2 years, 885 CV disease events occurred. The incidence rate of CV disease events was lowest among study participants who maintained a normal ECG status, followed by those with an inconsistent pattern, and then those who did not maintain their normal ECG status (trend p value <0.001). Similarly, the greater the number of visits with a normal ECG status, the lower was the incidence rate of CV disease events (trend p value <0.001). Maintaining (vs not maintaining) a normal ECG status was associated with a lower risk of CV disease, which was lower than that observed in those with inconsistent normal ECG pattern (trend p value <0.01). In conclusion, maintaining a normal ECG status over time is associated with low risk of CV disease in a dose-response fashion, suggesting its potential use as a monitoring tool for programs promoting CV health.",
author = "Soliman, {Elsayed Z.} and Zhang, {Zhu Ming} and Chen, {Lin Y.} and Tereshchenko, {Larisa G.} and Dan Arking and Alvaro Alonso",
year = "2017",
month = "1",
day = "15",
doi = "10.1016/j.amjcard.2016.09.051",
language = "English (US)",
volume = "119",
pages = "249--255",
journal = "American Journal of Cardiology",
issn = "0002-9149",
publisher = "Elsevier Inc.",
number = "2",

}

TY - JOUR

T1 - Usefulness of Maintaining a Normal Electrocardiogram Over Time for Predicting Cardiovascular Health

AU - Soliman, Elsayed Z.

AU - Zhang, Zhu Ming

AU - Chen, Lin Y.

AU - Tereshchenko, Larisa G.

AU - Arking, Dan

AU - Alonso, Alvaro

PY - 2017/1/15

Y1 - 2017/1/15

N2 - We hypothesized that maintaining a normal electrocardiogram (ECG) status over time is associated with low cardiovascular (CV) disease in a dose-response fashion and subsequently could be used to monitor programs aimed at promoting CV health. This analysis included 4,856 CV disease-free participants from the Atherosclerosis Risk in Communities study who had a normal ECG at baseline (1987 to 1989) and complete electrocardiographic data in subsequent 3 visits (1990 to 1992, 1993 to 1995, and 1996 to 1998). Participants were classified based on maintaining their normal ECG status during these 4 visits into “maintained,” “not maintained,” or “inconsistent” normal ECG status as defined by the Minnesota ECG classification. CV disease events (coronary heart disease, heart failure, and stroke) were adjudicated from Atherosclerosis Risk in Communities visit-4 through 2010. Over a median follow-up of 13.2 years, 885 CV disease events occurred. The incidence rate of CV disease events was lowest among study participants who maintained a normal ECG status, followed by those with an inconsistent pattern, and then those who did not maintain their normal ECG status (trend p value <0.001). Similarly, the greater the number of visits with a normal ECG status, the lower was the incidence rate of CV disease events (trend p value <0.001). Maintaining (vs not maintaining) a normal ECG status was associated with a lower risk of CV disease, which was lower than that observed in those with inconsistent normal ECG pattern (trend p value <0.01). In conclusion, maintaining a normal ECG status over time is associated with low risk of CV disease in a dose-response fashion, suggesting its potential use as a monitoring tool for programs promoting CV health.

AB - We hypothesized that maintaining a normal electrocardiogram (ECG) status over time is associated with low cardiovascular (CV) disease in a dose-response fashion and subsequently could be used to monitor programs aimed at promoting CV health. This analysis included 4,856 CV disease-free participants from the Atherosclerosis Risk in Communities study who had a normal ECG at baseline (1987 to 1989) and complete electrocardiographic data in subsequent 3 visits (1990 to 1992, 1993 to 1995, and 1996 to 1998). Participants were classified based on maintaining their normal ECG status during these 4 visits into “maintained,” “not maintained,” or “inconsistent” normal ECG status as defined by the Minnesota ECG classification. CV disease events (coronary heart disease, heart failure, and stroke) were adjudicated from Atherosclerosis Risk in Communities visit-4 through 2010. Over a median follow-up of 13.2 years, 885 CV disease events occurred. The incidence rate of CV disease events was lowest among study participants who maintained a normal ECG status, followed by those with an inconsistent pattern, and then those who did not maintain their normal ECG status (trend p value <0.001). Similarly, the greater the number of visits with a normal ECG status, the lower was the incidence rate of CV disease events (trend p value <0.001). Maintaining (vs not maintaining) a normal ECG status was associated with a lower risk of CV disease, which was lower than that observed in those with inconsistent normal ECG pattern (trend p value <0.01). In conclusion, maintaining a normal ECG status over time is associated with low risk of CV disease in a dose-response fashion, suggesting its potential use as a monitoring tool for programs promoting CV health.

UR - http://www.scopus.com/inward/record.url?scp=85006076433&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85006076433&partnerID=8YFLogxK

U2 - 10.1016/j.amjcard.2016.09.051

DO - 10.1016/j.amjcard.2016.09.051

M3 - Article

VL - 119

SP - 249

EP - 255

JO - American Journal of Cardiology

JF - American Journal of Cardiology

SN - 0002-9149

IS - 2

ER -