L'acido urico predice i livelli di proteina C-reattiva ed interleuchina-6 dopo tre anni di follow-up: Risultati dello studio InCHIANTI

Translated title of the contribution: Usefullness of uric acid to predict changes in C-reactive protein and interleukin-6 in 3-year period in Italians aged 21 to 91 years

Carmelinda Ruggiero, A. Cherubini, N. H. Nguyen, G. Dell'Aquila, B. Gasperini, R. Serra, M. Maggio, F. Lauretani, S. Bandineijj, U. Senin, L. Ferrucci

Research output: Contribution to journalArticle

Abstract

Aim: The role of uric acid (UA) in the process of atherotrombosis is controversial. Although serum UA has powerful antioxidant properties, epidemiological studies show that UA is a risk factor for cardiovascular diseases and is positively associated with proinflammatory markers. Methods: We investigated the relationship between baseline UA and changes in UA circulating levels with C-Reactive Protein (CRP) and interleukin-6 (IL-6) after 3 years of follow-up in a cohort of 892 Italian men and women aged 21-91 years. Participants had complete baseline and follow-up data on UA, inflammatory markers and covariates. An autoregressive approach was used to study such a relationship. Results: In adjusted analyses, baseline UA and changes in UA levels predicted a 3 years change in CRP (p = 0.028), but not IL-6 (p = 0.101). The relationship between UA and CRP persisted after adjustment for baseline ILL-6. Participants with high UA at baseline had progressively higher probability of developing clinically relevant elevated levels of IL-6 (> 2.5 pg/mL) and CRP (> 3.0 mg/L) over 3 years. Conclusions: Our study suggests that in a population-based cohort, baseline UA and changes in circulating UA levels over 3 years of follow-up predict changes in circulating CRP levels independent of r9levant confounders, including baseline IL-6 levels.

Translated title of the contributionUsefullness of uric acid to predict changes in C-reactive protein and interleukin-6 in 3-year period in Italians aged 21 to 91 years
Original languageItalian
Pages (from-to)123-131
Number of pages9
JournalGiornale di Gerontologia
Volume56
Issue number3
StatePublished - Jun 2008
Externally publishedYes

Keywords

  • Cardiovascular diseases
  • Inflammation
  • Inflammatory
  • Markers
  • Metabolism
  • Uric acid

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

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    Ruggiero, C., Cherubini, A., Nguyen, N. H., Dell'Aquila, G., Gasperini, B., Serra, R., Maggio, M., Lauretani, F., Bandineijj, S., Senin, U., & Ferrucci, L. (2008). L'acido urico predice i livelli di proteina C-reattiva ed interleuchina-6 dopo tre anni di follow-up: Risultati dello studio InCHIANTI. Giornale di Gerontologia, 56(3), 123-131.