Use of urinary PAH metabolites to assess PAH exposure intervention among coke oven workers

Soo Hun Cho, Daehee Kang, Jong Won Kang, Yeong Su Ju, Joohon Sung, Cheol Koo Lee, Song Kwon Lee, Young Sei Lee, Paul Timothy Strickland

Research output: Contribution to journalArticle

Abstract

To assess the effectiveness of protective skin coveralls in reducing skin contamination among coke-oven workers, 1-hydroxypyrene glucuronide (1- OHPG) was used as an internal dose marker of polycyclic aromatic hydrocarbon (PAH) exposure. Twenty coke-oven workers at a steel plant in South Korea provided their first morning void urine samples before beginning work, as well as postshift urine samples after working for five days with regular skin protection. Pre- and postshift urine samples from the same workers were collected after new skin coveralls made from Tyvek® had been worn during the week following regular skin protection. Urine samples were quantitated for 1- OHPG by immunoaffinity purification and HPLC with a fluorescence detector. The benzene-soluble fraction (BSF) of coke oven emissions (COE) in personal air samples from the 20 workers was also quantitated. To obtain information relating to smoking, job history, dietary habits, drug use, past medical history, and the use of personal protective equipment, a self-administered questionnaire was used. The mean age of study participants was 39.7 yr and the average length of employment was 12 yr (11 months - 18 yr). In 20 workers, there was a statistically significant correlation between ambient COE and urinary 1-OHPG levels during the period of regular skin protection (r=0.50, p

Original languageEnglish (US)
Pages (from-to)138-143
Number of pages6
JournalJournal of Occupational Health
Volume42
Issue number3
Publication statusPublished - May 2000

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Keywords

  • Coke-oven workers
  • Intervention
  • Urinary PAH metabolites

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Toxicology

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