Use of the coulombic interactions of the lanthanide series to identify two classes of Ca2+ binding sites in mitochondria

Research output: Contribution to journalArticle

Abstract

The degree of inhibition of respiration-dependent vs respiration-independent Ca2+ binding by rat liver mitochondria by different members of the lanthanide family was used to establish the existence of two different classes of Ca2+ binding sites. The distinction is based on the differences in cation:site interactions between the two classes of sites and the members of the lanthanide series. Lanthanide inhibition of respiration-dependent Ca2+ uptake suggests that the binding site is specific for the calcium ion. Those members of the lanthanide family whose ionic radii are nearer that of Ca2+ are the best inhibitors. The inhibition of respiration-independent Ca2+ binding is much different, indicating non-specific cation absorption.

Original languageEnglish (US)
Pages (from-to)624-630
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume78
Issue number2
DOIs
StatePublished - Sep 23 1977

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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