Use of single-site-functionalized PEG dendrons to prepare gene vectors that penetrate human mucus barriers

Anthony J. Kim; Nicholas J. Boylan; Jung Soo Suk; Minyoung Hwangbo; Tao Yu; Benjamin S. Schuster; Liudimila Cebotaru; Wojciech G. Lesniak; Joon Seok Oh; Pichet Adstamongkonkul; Ashley Y. Choi; Rangaramanujam M. Kannan; Justin Hanes

doi:10.1002/anie.201208556

Use of single-site-functionalized PEG dendrons to prepare gene vectors that penetrate human mucus barriers

Anthony J. Kim, Nicholas J. Boylan, Jung Soo Suk, Minyoung Hwangbo, Tao Yu, Benjamin S. Schuster, Liudimila Cebotaru, Wojciech G. Lesniak, Joon Seok Oh, Pichet Adstamongkonkul, Ashley Y. Choi, Rangaramanujam M. Kannan, Justin Hanes

School of Medicine

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

Mucus-penetrating DNA nanoparticles: A novel synthetic strategy was used to achieve a dense PEG coating on the surface of cationic polymer-based DNA nanoparticles. The dense PEG coating (blue in scheme) endows the nanoparticles with a muco-inert surface, which enables their rapid mucus penetration (trajectory indicated by gray line) and provides efficient gene transfer in various cell types.

Original language	English (US)
Pages (from-to)	3985-3988
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	52
Issue number	14
DOIs	https://doi.org/10.1002/anie.201208556
State	Published - Apr 2 2013

Keywords

DNA nanoparticles
cystic fibrosis
gene therapy
mucus-penetrating particles
nanotechnology

ASJC Scopus subject areas

Catalysis
Chemistry(all)

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10.1002/anie.201208556

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Kim, A. J., Boylan, N. J., Suk, J. S., Hwangbo, M., Yu, T., Schuster, B. S., Cebotaru, L., Lesniak, W. G., Oh, J. S., Adstamongkonkul, P., Choi, A. Y., Kannan, R. M., & Hanes, J. (2013). Use of single-site-functionalized PEG dendrons to prepare gene vectors that penetrate human mucus barriers. Angewandte Chemie - International Edition, 52(14), 3985-3988. https://doi.org/10.1002/anie.201208556

Kim, AJ, Boylan, NJ, Suk, JS, Hwangbo, M, Yu, T, Schuster, BS, Cebotaru, L , Lesniak, WG, Oh, JS, Adstamongkonkul, P, Choi, AY, Kannan, RM & Hanes, J 2013, 'Use of single-site-functionalized PEG dendrons to prepare gene vectors that penetrate human mucus barriers', Angewandte Chemie - International Edition, vol. 52, no. 14, pp. 3985-3988. https://doi.org/10.1002/anie.201208556

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AU - Schuster, Benjamin S.

AU - Cebotaru, Liudimila

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AU - Oh, Joon Seok

AU - Adstamongkonkul, Pichet

AU - Choi, Ashley Y.

AU - Kannan, Rangaramanujam M.

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KW - gene therapy

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Use of single-site-functionalized PEG dendrons to prepare gene vectors that penetrate human mucus barriers

Abstract

Keywords

ASJC Scopus subject areas

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