TY - JOUR
T1 - Use of serum biomarkers to predict cerebral hypoxia after severe traumatic brain injury
AU - Stein, Deborah M.
AU - Lindell, Allison L.
AU - Murdock, Karen R.
AU - Kufera, Joseph A.
AU - Menaker, Jay
AU - Bochicchio, Grant V.
AU - Aarabi, Bizhan
AU - Scalea, Thomas M.
PY - 2012/4/10
Y1 - 2012/4/10
N2 - The management of severe traumatic brain injury (TBI) focuses on prevention and treatment of secondary insults such as cerebral hypoxia (CH). There are a number of biomarkers that are thought to play a part in secondary injury following severe TBI. This study evaluates the association between S100β, neuron-specific enolase (NSE), and glial fibrillary acidic protein (GFAP), detected in the serum of severe TBI patients and CH as measured by brain tissue oxygen partial pressure (Pbo 2). Patients with severe TBI were prospectively enrolled. Pressure times time (PTD; mm Hg*h), measuring the depth and duration of CH, was calculated for 12-h periods for episodes of moderate (Pbo 2 <20mm Hg) and severe (Pbo 2 <15mm Hg) CH, and compared to serum levels of S100β, NSE, and GFAP drawn prior to periods of monitoring. An adjusted mixed model analysis was applied as was receiver operating characteristic (ROC) curve analysis. Of 76 patients enrolled, 24 had Pbo 2 monitoring. One hundred and thirty serum samples were matched with 12-h periods of monitoring. Significant associations were found in adjusted analyses between increasing serum levels of S100β (coefficient=0.57, 0.56; p22
AB - The management of severe traumatic brain injury (TBI) focuses on prevention and treatment of secondary insults such as cerebral hypoxia (CH). There are a number of biomarkers that are thought to play a part in secondary injury following severe TBI. This study evaluates the association between S100β, neuron-specific enolase (NSE), and glial fibrillary acidic protein (GFAP), detected in the serum of severe TBI patients and CH as measured by brain tissue oxygen partial pressure (Pbo 2). Patients with severe TBI were prospectively enrolled. Pressure times time (PTD; mm Hg*h), measuring the depth and duration of CH, was calculated for 12-h periods for episodes of moderate (Pbo 2 <20mm Hg) and severe (Pbo 2 <15mm Hg) CH, and compared to serum levels of S100β, NSE, and GFAP drawn prior to periods of monitoring. An adjusted mixed model analysis was applied as was receiver operating characteristic (ROC) curve analysis. Of 76 patients enrolled, 24 had Pbo 2 monitoring. One hundred and thirty serum samples were matched with 12-h periods of monitoring. Significant associations were found in adjusted analyses between increasing serum levels of S100β (coefficient=0.57, 0.56; p22
KW - biomarkers
KW - clinical management of CNS injury
KW - traumatic brain injury
UR - http://www.scopus.com/inward/record.url?scp=84859899590&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84859899590&partnerID=8YFLogxK
U2 - 10.1089/neu.2011.2149
DO - 10.1089/neu.2011.2149
M3 - Article
C2 - 22360297
AN - SCOPUS:84859899590
SN - 0897-7151
VL - 29
SP - 1140
EP - 1149
JO - Journal of Neurotrauma
JF - Journal of Neurotrauma
IS - 6
ER -