Use of regenerative tissue for urinary diversion

Nikolai A. Sopko, Max Kates, Trinity Bivalacqua

Research output: Contribution to journalArticle

Abstract

Purpose of review There is a large interest in developing tissue engineered urinary diversions (TEUDs) in order to reduce the significant morbidity that results from utilization of the alimentary tract in the urinary system. Preclinical trials have been favorable but durable clinical results have not been realized. The present article will review the pertinent concepts for the clinical development of a successful TEUD. Recent findings Studies continue to identify novel scaffold materials and cell populations that are combined to generate TEUDs. Scaffold composition range from synthetic material to decelluarized bladder tissue. Cell types vary from fully differentiated adult populations such as smooth muscle cells isolated from the bladder to stem cell populations including mesenchymal stem cells and induced pluripotent stem cells. Each scaffold and cell type has its advantages and disadvantages with no clear superior component having been identified. Recent clinical trials have been disappointing, supporting the need for additional investigation. Summary Successful application of TEUDs requires a complex interplay of scaffold, cells, and host environment. Studies continue to investigate candidate scaffold materials, cell populations, and combinations thereof to determine which will best recapitulate the complex structure of the human genitourinary tract.

Original languageEnglish (US)
Pages (from-to)578-585
Number of pages8
JournalCurrent Opinion in Urology
Volume25
Issue number6
DOIs
StatePublished - Nov 11 2015

Fingerprint

Urinary Diversion
Population
Urinary Bladder
Induced Pluripotent Stem Cells
Urinary Tract
Mesenchymal Stromal Cells
Smooth Muscle Myocytes
Stem Cells
Clinical Trials
Morbidity

Keywords

  • Regenerative medicine
  • Scaffolds
  • Stem cells
  • Tissue engineering
  • Urothelium

ASJC Scopus subject areas

  • Urology

Cite this

Use of regenerative tissue for urinary diversion. / Sopko, Nikolai A.; Kates, Max; Bivalacqua, Trinity.

In: Current Opinion in Urology, Vol. 25, No. 6, 11.11.2015, p. 578-585.

Research output: Contribution to journalArticle

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