Use of preimplantation genetic diagnosis and preimplantation genetic screening in the United States: A Society for Assisted Reproductive Technology Writing Group paper

Elizabeth S. Ginsburg, Valerie L. Baker, Catherine Racowsky, Ethan Wantman, James Goldfarb, Judy E. Stern

Research output: Contribution to journalArticle

Abstract

Objective: To comprehensively report Society for Assisted Reproductive Technology (SART) member program usage of preimplantation genetic testing (PGT), preimplantation genetic diagnosis (PGD) for diagnosis of specific conditions, and preimplantation genetic screening for aneuploidy (PGS). Design: Retrospective study. Setting: United States SART cohort data. Patient(s): Women undergoing a PGT cycle in which at least one embryo underwent biopsy. Intervention(s): PGT. Main Outcome Measure(s): PGT use, indications, and delivery rates. Result(s): Of 190,260 fresh, nondonor assisted reproductive technology (ART) cycles reported to SART CORS in 2007-2008, 8,337 included PGT. Of 6,971 cycles with a defined indication, 1,382 cycles were for genetic diagnosis, 3,645 for aneuploidy screening (PGS), 527 for translocation, and 1,417 for elective sex election. Although the total number of fresh, autologous cycles increased by 3.6% from 2007 to 2008, the percentage of cycles with PGT decreased by 5.8% (4,293 in 2007 and 4,044 in 2008). As a percentage of fresh, nondonor ART cycles, use dropped from 4.6% (4,293/93,433) in 2007 to 4.2% (4,044/96,827) in 2008. The primary indication for PGT was PGS: cycles performed for this indication decreased (-8.0%). PGD use for single-gene defects (+3.2%), elective sex selection (+5.3%), and translocation analysis (+0.5%) increased. PGT usage varied significantly by geographical region. Conclusion(s): PGT usage in the United States decreased between 2007 and 2008 owing to a decrease in PGS. Use of elective sex selection increased. High transfer cancellation rates correlated with reduced live-birth rates for some PGT indications.

Original languageEnglish (US)
Pages (from-to)865-868
Number of pages4
JournalFertility and sterility
Volume96
Issue number4
DOIs
StatePublished - Oct 1 2011
Externally publishedYes

Keywords

  • Embryo biopsy
  • aneuploidy
  • elective sex selection
  • preimplantation genetic diagnosis
  • preimplantation genetic screening
  • translocation

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

Fingerprint Dive into the research topics of 'Use of preimplantation genetic diagnosis and preimplantation genetic screening in the United States: A Society for Assisted Reproductive Technology Writing Group paper'. Together they form a unique fingerprint.

  • Cite this