Use of PNA FISH for blood cultures growing Gram-positive cocci in chains without a concomitant antibiotic stewardship intervention does not improve time to appropriate antibiotic therapy

Sara Cosgrove, David X. Li, Pranita Tamma, Edina Avdic, Eric Hadhazy, Teresa Wakefield, Michael Gherna, Karen C Carroll

Research output: Contribution to journalArticlepeer-review

Abstract

Peptide nucleic acid fluorescence in situ hybridization (PNA FISH) is a rapid diagnostic assay that can identify certain organisms growing in blood cultures 30-90 min from the time of positive Gram-stain. Existing studies have demonstrated a clinical utility with this assay when antibiotic stewardship programs assist clinicians with interpreting the results. However, the benefit of these rapid assays in the absence of concomitant antibiotic stewardship involvement is unclear. In this randomized study of 220 patients with enterococcal or streptococcal bacteremia, we found that PNA FISH, in the absence of concomitant input from an antibiotic stewardship program, had no impact on time to effective or optimal therapy, length of hospital stay, or in-hospital mortality. Our results suggest that in the absence of guidance from an antibiotic stewardship program, the clinical benefits of rapid diagnostic microbiological tools may be reduced.

Original languageEnglish (US)
JournalDiagnostic Microbiology and Infectious Disease
DOIs
StateAccepted/In press - Apr 11 2016

Keywords

  • Antibiotic stewardship
  • Bacteremia
  • PNA FISH
  • Rapid diagnostics

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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