Use of parallel-synthesis combinatorial libraries for rapid identification of potent FKBP12 inhibitors

Chi Choi, Jia He Li, Mark Vaal, Christine Thomas, David Limburg, Yong Qian Wu, Yi Chen, Raj Soni, Chad Scott, Douglas T. Ross, Hong Guo, Pamela Howorth, Heather Valentine, Shi Liang, Dawn Spicer, Mike Fuller, Joseph Steiner, Gregory S. Hamilton

Research output: Contribution to journalArticle

Abstract

Using simple, inexpensive equipment, we have used solution-phase parallel synthesis to rapidly prepare hundreds of sulfonamide- and urea-containing FKBP inhibitors, resulting in rapid identification of extremely potent compounds in these series.

Original languageEnglish (US)
Pages (from-to)1421-1428
Number of pages8
JournalBioorganic and Medicinal Chemistry Letters
Volume12
Issue number10
DOIs
StatePublished - May 20 2002
Externally publishedYes

Fingerprint

Tacrolimus Binding Protein 1A
Tacrolimus Binding Proteins
Sulfonamides
Urea
Equipment and Supplies

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Use of parallel-synthesis combinatorial libraries for rapid identification of potent FKBP12 inhibitors. / Choi, Chi; Li, Jia He; Vaal, Mark; Thomas, Christine; Limburg, David; Wu, Yong Qian; Chen, Yi; Soni, Raj; Scott, Chad; Ross, Douglas T.; Guo, Hong; Howorth, Pamela; Valentine, Heather; Liang, Shi; Spicer, Dawn; Fuller, Mike; Steiner, Joseph; Hamilton, Gregory S.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 12, No. 10, 20.05.2002, p. 1421-1428.

Research output: Contribution to journalArticle

Choi, C, Li, JH, Vaal, M, Thomas, C, Limburg, D, Wu, YQ, Chen, Y, Soni, R, Scott, C, Ross, DT, Guo, H, Howorth, P, Valentine, H, Liang, S, Spicer, D, Fuller, M, Steiner, J & Hamilton, GS 2002, 'Use of parallel-synthesis combinatorial libraries for rapid identification of potent FKBP12 inhibitors', Bioorganic and Medicinal Chemistry Letters, vol. 12, no. 10, pp. 1421-1428. https://doi.org/10.1016/S0960-894X(02)00147-6
Choi, Chi ; Li, Jia He ; Vaal, Mark ; Thomas, Christine ; Limburg, David ; Wu, Yong Qian ; Chen, Yi ; Soni, Raj ; Scott, Chad ; Ross, Douglas T. ; Guo, Hong ; Howorth, Pamela ; Valentine, Heather ; Liang, Shi ; Spicer, Dawn ; Fuller, Mike ; Steiner, Joseph ; Hamilton, Gregory S. / Use of parallel-synthesis combinatorial libraries for rapid identification of potent FKBP12 inhibitors. In: Bioorganic and Medicinal Chemistry Letters. 2002 ; Vol. 12, No. 10. pp. 1421-1428.
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