Use of parallel-synthesis combinatorial libraries for rapid identification of potent FKBP12 inhibitors

Chi Choi; Jia He Li; Mark Vaal; Christine Thomas; David Limburg; Yong Qian Wu; Yi Chen; Raj Soni; Chad Scott; Douglas T. Ross; Hong Guo; Pamela Howorth; Heather Valentine; Shi Liang; Dawn Spicer; Mike Fuller; Joseph Steiner; Gregory S. Hamilton

doi:10.1016/S0960-894X(02)00147-6

Use of parallel-synthesis combinatorial libraries for rapid identification of potent FKBP12 inhibitors

Chi Choi, Jia He Li, Mark Vaal, Christine Thomas, David Limburg, Yong Qian Wu, Yi Chen, Raj Soni, Chad Scott, Douglas T. Ross, Hong Guo, Pamela Howorth, Heather Valentine, Shi Liang, Dawn Spicer, Mike Fuller, Joseph Steiner, Gregory S. Hamilton

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Using simple, inexpensive equipment, we have used solution-phase parallel synthesis to rapidly prepare hundreds of sulfonamide- and urea-containing FKBP inhibitors, resulting in rapid identification of extremely potent compounds in these series.

Original language	English (US)
Pages (from-to)	1421-1428
Number of pages	8
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	12
Issue number	10
DOIs	https://doi.org/10.1016/S0960-894X(02)00147-6
State	Published - May 20 2002
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

Access to Document

10.1016/S0960-894X(02)00147-6

Cite this

Choi, C., Li, J. H., Vaal, M., Thomas, C., Limburg, D., Wu, Y. Q., Chen, Y., Soni, R., Scott, C., Ross, D. T., Guo, H., Howorth, P., Valentine, H., Liang, S., Spicer, D., Fuller, M., Steiner, J., & Hamilton, G. S. (2002). Use of parallel-synthesis combinatorial libraries for rapid identification of potent FKBP12 inhibitors. Bioorganic and Medicinal Chemistry Letters, 12(10), 1421-1428. https://doi.org/10.1016/S0960-894X(02)00147-6

Choi, C, Li, JH, Vaal, M, Thomas, C, Limburg, D, Wu, YQ, Chen, Y, Soni, R, Scott, C, Ross, DT, Guo, H, Howorth, P, Valentine, H, Liang, S, Spicer, D, Fuller, M, Steiner, J & Hamilton, GS 2002, 'Use of parallel-synthesis combinatorial libraries for rapid identification of potent FKBP12 inhibitors', Bioorganic and Medicinal Chemistry Letters, vol. 12, no. 10, pp. 1421-1428. https://doi.org/10.1016/S0960-894X(02)00147-6

@article{1708533f627a464695e756877776e516,

title = "Use of parallel-synthesis combinatorial libraries for rapid identification of potent FKBP12 inhibitors",

abstract = "Using simple, inexpensive equipment, we have used solution-phase parallel synthesis to rapidly prepare hundreds of sulfonamide- and urea-containing FKBP inhibitors, resulting in rapid identification of extremely potent compounds in these series.",

author = "Chi Choi and Li, {Jia He} and Mark Vaal and Christine Thomas and David Limburg and Wu, {Yong Qian} and Yi Chen and Raj Soni and Chad Scott and Ross, {Douglas T.} and Hong Guo and Pamela Howorth and Heather Valentine and Shi Liang and Dawn Spicer and Mike Fuller and Joseph Steiner and Hamilton, {Gregory S.}",

year = "2002",

month = may,

day = "20",

doi = "10.1016/S0960-894X(02)00147-6",

language = "English (US)",

volume = "12",

pages = "1421--1428",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Limited",

number = "10",

}

TY - JOUR

T1 - Use of parallel-synthesis combinatorial libraries for rapid identification of potent FKBP12 inhibitors

AU - Choi, Chi

AU - Li, Jia He

AU - Vaal, Mark

AU - Thomas, Christine

AU - Limburg, David

AU - Wu, Yong Qian

AU - Chen, Yi

AU - Soni, Raj

AU - Scott, Chad

AU - Ross, Douglas T.

AU - Guo, Hong

AU - Howorth, Pamela

AU - Valentine, Heather

AU - Liang, Shi

AU - Spicer, Dawn

AU - Fuller, Mike

AU - Steiner, Joseph

AU - Hamilton, Gregory S.

PY - 2002/5/20

Y1 - 2002/5/20

N2 - Using simple, inexpensive equipment, we have used solution-phase parallel synthesis to rapidly prepare hundreds of sulfonamide- and urea-containing FKBP inhibitors, resulting in rapid identification of extremely potent compounds in these series.

AB - Using simple, inexpensive equipment, we have used solution-phase parallel synthesis to rapidly prepare hundreds of sulfonamide- and urea-containing FKBP inhibitors, resulting in rapid identification of extremely potent compounds in these series.

UR - http://www.scopus.com/inward/record.url?scp=18344379671&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=18344379671&partnerID=8YFLogxK

U2 - 10.1016/S0960-894X(02)00147-6

DO - 10.1016/S0960-894X(02)00147-6

M3 - Article

C2 - 11992790

AN - SCOPUS:18344379671

SN - 0960-894X

VL - 12

SP - 1421

EP - 1428

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 10

ER -

Use of parallel-synthesis combinatorial libraries for rapid identification of potent FKBP12 inhibitors

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this