Use of parallel-synthesis combinatorial libraries for rapid identification of potent FKBP12 inhibitors

Chi Choi, Jia He Li, Mark Vaal, Christine Thomas, David Limburg, Yong Qian Wu, Yi Chen, Raj Soni, Chad Scott, Douglas T. Ross, Hong Guo, Pamela Howorth, Heather Valentine, Shi Liang, Dawn Spicer, Mike Fuller, Joseph Steiner, Gregory S. Hamilton

Research output: Contribution to journalArticle

Abstract

Using simple, inexpensive equipment, we have used solution-phase parallel synthesis to rapidly prepare hundreds of sulfonamide- and urea-containing FKBP inhibitors, resulting in rapid identification of extremely potent compounds in these series.

Original languageEnglish (US)
Pages (from-to)1421-1428
Number of pages8
JournalBioorganic and Medicinal Chemistry Letters
Volume12
Issue number10
DOIs
StatePublished - May 20 2002

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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    Choi, C., Li, J. H., Vaal, M., Thomas, C., Limburg, D., Wu, Y. Q., Chen, Y., Soni, R., Scott, C., Ross, D. T., Guo, H., Howorth, P., Valentine, H., Liang, S., Spicer, D., Fuller, M., Steiner, J., & Hamilton, G. S. (2002). Use of parallel-synthesis combinatorial libraries for rapid identification of potent FKBP12 inhibitors. Bioorganic and Medicinal Chemistry Letters, 12(10), 1421-1428. https://doi.org/10.1016/S0960-894X(02)00147-6