Use of loteprednol for routine prophylaxis after photorefractive keratectomy

Mark D. Mifflin, Lisa L. Leishman, Steven M. Christiansen, Shameema Sikder, Maylon Hsu, Majid Moshirfar

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The purpose of this work is to report our experience using loteprednol 0.5% for routine prophylaxis after photorefractive keratectomy in an academic refractive surgery center. Materials and methods: Photorefractive keratectomy was performed on 579 eyes from 316 patients in this retrospective chart review of patients treated postoperatively with either fluorometholone 0.1% (273 eyes) or loteprednol 0.5% (306 eyes). Primary outcome measures at 6 months included uncorrected distance visual acuity, corrected distance visual acuity, and manifest refraction spherical equivalent. Secondary outcome measures were incidence of corneal haze and increased intraocular pressure. Results: There were no statistically significant differences in preoperative characteristics between the two groups when comparing age, sex, best-corrected visual acuity, spherical equivalent, or keratometry. Both groups achieved excellent visual outcomes, with a mean uncorrected distance visual acuity (logMAR) of 0.004 ± 1.4 in the fluorometholone group and -0.028 ± 1.1 in the loteprednol group (P = 0.013) at 6 months. Postoperative corneal haze and increased intraocular pressure were uncommon and not statistically different between the groups. Conclusion: Loteprednol 0.5% performed similarly to fluorometholone 0.1% when used for prophylaxis following photorefractive keratectomy. The incidence of haze and increased intraocular pressure were similar between the two groups.

Original languageEnglish (US)
Pages (from-to)653-659
Number of pages7
JournalClinical Ophthalmology
Volume6
Issue number1
DOIs
StatePublished - Apr 30 2012

Keywords

  • Fluorometholone
  • Loteprednol
  • Photorefractive keratectomy

ASJC Scopus subject areas

  • Ophthalmology

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