Use of larynx-preservation strategies in the treatment of laryngeal cancer: American society of clinical oncology clinical practice guideline update

Arlene A. Forastiere, Nofisat Ismaila, Jan S. Lewin, Cherie Ann Nathan, David J. Adelstein, Avraham Eisbruch, Gail Fass, Susan G. Fisher, Scott A. Laurie, Quynh Thu Le, Bernard O'Malley, William M. Mendenhall, Snehal Patel, David G. Pfister, Anthony F. Provenzano, Randy Weber, Gregory S. Weinstein, Gregory T. Wolf

Research output: Contribution to journalReview article

Abstract

Purpose To update the guideline recommendations on the use of larynx-preservation strategies in the treatment of laryngeal cancer. Methods An Expert Panel updated the systematic review of the literature for the period from January 2005 to May 2017. Results The panel confirmed that the use of a larynx-preservation approach for appropriately selected patients does not compromise survival. No larynx-preservation approach offered a survival advantage comparedwith total laryngectomy and adjuvant therapy as indicated. Changeswere supported for the use of endoscopic surgical resection in patients with limited disease (T1, T2) and for initial total laryngectomy in patients with T4a disease or with severe pretreatment laryngeal dysfunction. New recommendations for positron emission tomography imaging for the evaluation of regional nodes after treatment and best measures for evaluating voice and swallowing function were added. Recommendations Patients with T1, T2 laryngeal cancer should be treated initially with intent to preserve the larynx by using endoscopic resection or radiation therapy, with either leading to similar outcomes. For patients with locally advanced (T3, T4) disease, organ-preservation surgery, combined chemotherapy and radiation, or radiation alone offer the potential for larynx preservation without compromising overall survival. For selected patients with extensive T3 or large T4a lesions and/or poor pretreatment laryngeal function, better survival rates and quality of life may be achieved with total laryngectomy. Patients with clinically involved regional cervical nodes (N+) who have a complete clinical and radiologic imaging response after chemoradiation do not require elective neck dissection. All patients should undergo a pretreatment baseline assessment of voice and swallowing function and receive counseling with regard to the potential impact of treatment options on voice, swallowing, and quality of life. Additional information is available at www.asco.org/head-neck-cancer-guidelines and www.asco.org/guidelineswiki.

Original languageEnglish (US)
Pages (from-to)1143-1169
Number of pages27
JournalJournal of Clinical Oncology
Volume36
Issue number11
DOIs
StatePublished - Apr 10 2018

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Laryngeal Neoplasms
Medical Oncology
Larynx
Practice Guidelines
Laryngectomy
Deglutition
Therapeutics
Survival
Quality of Life
Guidelines
Radiation
Voice Quality
Organ Preservation
Neck Dissection
Head and Neck Neoplasms
Positron-Emission Tomography
Counseling
Radiotherapy
Survival Rate
Drug Therapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Use of larynx-preservation strategies in the treatment of laryngeal cancer : American society of clinical oncology clinical practice guideline update. / Forastiere, Arlene A.; Ismaila, Nofisat; Lewin, Jan S.; Nathan, Cherie Ann; Adelstein, David J.; Eisbruch, Avraham; Fass, Gail; Fisher, Susan G.; Laurie, Scott A.; Le, Quynh Thu; O'Malley, Bernard; Mendenhall, William M.; Patel, Snehal; Pfister, David G.; Provenzano, Anthony F.; Weber, Randy; Weinstein, Gregory S.; Wolf, Gregory T.

In: Journal of Clinical Oncology, Vol. 36, No. 11, 10.04.2018, p. 1143-1169.

Research output: Contribution to journalReview article

Forastiere, AA, Ismaila, N, Lewin, JS, Nathan, CA, Adelstein, DJ, Eisbruch, A, Fass, G, Fisher, SG, Laurie, SA, Le, QT, O'Malley, B, Mendenhall, WM, Patel, S, Pfister, DG, Provenzano, AF, Weber, R, Weinstein, GS & Wolf, GT 2018, 'Use of larynx-preservation strategies in the treatment of laryngeal cancer: American society of clinical oncology clinical practice guideline update', Journal of Clinical Oncology, vol. 36, no. 11, pp. 1143-1169. https://doi.org/10.1200/JCO.2017.75.7385
Forastiere, Arlene A. ; Ismaila, Nofisat ; Lewin, Jan S. ; Nathan, Cherie Ann ; Adelstein, David J. ; Eisbruch, Avraham ; Fass, Gail ; Fisher, Susan G. ; Laurie, Scott A. ; Le, Quynh Thu ; O'Malley, Bernard ; Mendenhall, William M. ; Patel, Snehal ; Pfister, David G. ; Provenzano, Anthony F. ; Weber, Randy ; Weinstein, Gregory S. ; Wolf, Gregory T. / Use of larynx-preservation strategies in the treatment of laryngeal cancer : American society of clinical oncology clinical practice guideline update. In: Journal of Clinical Oncology. 2018 ; Vol. 36, No. 11. pp. 1143-1169.
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AU - Nathan, Cherie Ann

AU - Adelstein, David J.

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AU - Fisher, Susan G.

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AU - Le, Quynh Thu

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N2 - Purpose To update the guideline recommendations on the use of larynx-preservation strategies in the treatment of laryngeal cancer. Methods An Expert Panel updated the systematic review of the literature for the period from January 2005 to May 2017. Results The panel confirmed that the use of a larynx-preservation approach for appropriately selected patients does not compromise survival. No larynx-preservation approach offered a survival advantage comparedwith total laryngectomy and adjuvant therapy as indicated. Changeswere supported for the use of endoscopic surgical resection in patients with limited disease (T1, T2) and for initial total laryngectomy in patients with T4a disease or with severe pretreatment laryngeal dysfunction. New recommendations for positron emission tomography imaging for the evaluation of regional nodes after treatment and best measures for evaluating voice and swallowing function were added. Recommendations Patients with T1, T2 laryngeal cancer should be treated initially with intent to preserve the larynx by using endoscopic resection or radiation therapy, with either leading to similar outcomes. For patients with locally advanced (T3, T4) disease, organ-preservation surgery, combined chemotherapy and radiation, or radiation alone offer the potential for larynx preservation without compromising overall survival. For selected patients with extensive T3 or large T4a lesions and/or poor pretreatment laryngeal function, better survival rates and quality of life may be achieved with total laryngectomy. Patients with clinically involved regional cervical nodes (N+) who have a complete clinical and radiologic imaging response after chemoradiation do not require elective neck dissection. All patients should undergo a pretreatment baseline assessment of voice and swallowing function and receive counseling with regard to the potential impact of treatment options on voice, swallowing, and quality of life. Additional information is available at www.asco.org/head-neck-cancer-guidelines and www.asco.org/guidelineswiki.

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