Use of isolated brain capillaries and cultured endothelial cells to study the blood-brain barrier

G. W. Goldstein, A. Lorris Betz, P. D. Bowman

Research output: Contribution to journalArticle

Abstract

Brain capillary endothelial cells are responsible for forming the blood-brain barrier (BBB). Methods are now available to isolate microvessels from brain and study their biochemical and transport characteristics. From these investigations, new ideas have been proposed concerning the role of endothelial cells in the function of the BBB. More recently, success in culturing endothelial cells from brain microvessels has opened the way for novel approaches to the study of the regulation of endothelial cell permeability. We anticipate continued rapid progress in this area and expect that this will lead to a better understanding of the mechanisms involved in the regulation of BBB permeability and brain capillary function.

Original languageEnglish (US)
Pages (from-to)191-195
Number of pages5
JournalFederation Proceedings
Volume43
Issue number2
StatePublished - Jan 1 1984
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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