Use of haplotype analysis in the beta-globin gene cluster to discover beta-thalassemia mutations.

Haig Kazazian, S. E. Antonarakis, T. Cheng, C. D. Boehm, P. G. Waber

Research output: Contribution to journalArticle

Abstract

DNA polymorphisms have been of great value in defining a small number of common sequences in the beta-globin gene cluster and a region within which recombination may be restricted. Moreover, they have led to a screening procedure that not only has been of great value for the molecular characterization of beta-thalassemia mutations but also has implications for the characterization of other single-gene disorders.

Original languageEnglish (US)
Pages (from-to)91-98
Number of pages8
JournalProgress in Clinical and Biological Research
Volume134
StatePublished - 1983
Externally publishedYes

Fingerprint

beta-Globins
beta-Thalassemia
Multigene Family
Haplotypes
Genetic Recombination
Mutation
DNA
Genes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Use of haplotype analysis in the beta-globin gene cluster to discover beta-thalassemia mutations. / Kazazian, Haig; Antonarakis, S. E.; Cheng, T.; Boehm, C. D.; Waber, P. G.

In: Progress in Clinical and Biological Research, Vol. 134, 1983, p. 91-98.

Research output: Contribution to journalArticle

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