Use of engineered Schwann cells in peripheral neuropathy: Hopes and hazards

Helmar C. Lehmann; Ahmet Höke

doi:10.1016/j.brainres.2015.10.040

Use of engineered Schwann cells in peripheral neuropathy: Hopes and hazards

Helmar C. Lehmann, Ahmet Höke

School of Medicine

Research output: Contribution to journal › Review article › peer-review

24 Scopus citations

Abstract

Many diseases of the peripheral nervous system affect the function of Schwann cells. Recent developments in stem cell technology offer the opportunity to engineer stem cell derived glial cell populations that reveal essential phenotypic characteristics of Schwann cells including growth support and myelination of peripheral axons. Potential applications of these cells include its use as platform for human cell-based disease models as well as potential source for cell transplantation strategies. In this review we provide an update on the latest developments in engineering Schwann cells as diagnostic tools or for cell replacement therapies in peripheral neuropathic conditions. This article is part of a Special Issue entitled PSC and the brain.

Original language	English (US)
Pages (from-to)	97-104
Number of pages	8
Journal	Brain research
Volume	1638
DOIs	https://doi.org/10.1016/j.brainres.2015.10.040
State	Published - May 1 2016

Keywords

Myelination
Nerve injury
Peripheral nerve
Regeneration
Schwann cells

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/j.brainres.2015.10.040

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title = "Use of engineered Schwann cells in peripheral neuropathy: Hopes and hazards",

abstract = "Many diseases of the peripheral nervous system affect the function of Schwann cells. Recent developments in stem cell technology offer the opportunity to engineer stem cell derived glial cell populations that reveal essential phenotypic characteristics of Schwann cells including growth support and myelination of peripheral axons. Potential applications of these cells include its use as platform for human cell-based disease models as well as potential source for cell transplantation strategies. In this review we provide an update on the latest developments in engineering Schwann cells as diagnostic tools or for cell replacement therapies in peripheral neuropathic conditions. This article is part of a Special Issue entitled PSC and the brain.",

keywords = "Myelination, Nerve injury, Peripheral nerve, Regeneration, Schwann cells",

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AB - Many diseases of the peripheral nervous system affect the function of Schwann cells. Recent developments in stem cell technology offer the opportunity to engineer stem cell derived glial cell populations that reveal essential phenotypic characteristics of Schwann cells including growth support and myelination of peripheral axons. Potential applications of these cells include its use as platform for human cell-based disease models as well as potential source for cell transplantation strategies. In this review we provide an update on the latest developments in engineering Schwann cells as diagnostic tools or for cell replacement therapies in peripheral neuropathic conditions. This article is part of a Special Issue entitled PSC and the brain.

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KW - Regeneration

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Use of engineered Schwann cells in peripheral neuropathy: Hopes and hazards

Abstract

Keywords

ASJC Scopus subject areas

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