TY - JOUR
T1 - Use of dietary phytochemicals to target inflammation, fibrosis, proliferation, and angiogenesis in uterine tissues
T2 - Promising options for prevention and treatment of uterine fibroids?
AU - Islam, Md Soriful
AU - Akhtar, Most Mauluda
AU - Ciavattini, Andrea
AU - Giannubilo, Stefano Raffaele
AU - Protic, Olga
AU - Janjusevic, Milijana
AU - Procopio, Antonio Domenico
AU - Segars, James H.
AU - Castellucci, Mario
AU - Ciarmela, Pasquapina
PY - 2014/8
Y1 - 2014/8
N2 - Uterine leiomyomas (fibroids, myomas) are the most common benign tumors of female reproductive tract. They are highly prevalent, with 70-80% of women burdened by the end of their reproductive years. Fibroids are a leading cause of pelvic pain, abnormal vaginal bleeding, pressure on the bladder, miscarriage, and infertility. They are the leading indication for hysterectomy, and costs exceed 6 billion dollars annually in the United States. Unfortunately, no long-term medical treatments are available. Dysregulation of inflammatory processes are thought to be involved in the initiation of leiomyoma and extracellular matrix deposition, cell proliferation, and angiogenesis are the key cellular events implicated in leiomyoma growth. In modern pharmaceutical industries, dietary phytochemicals are used as source of new potential drugs for many kinds of tumors. Dietary phytochemicals may exert therapeutic effects by interfering with key cellular events of the tumorigenesis process. At present, a negligible number of phytochemicals have been tested as therapeutic agents against fibroids. In this context, our aim was to introduce some of the potential dietary phytochemicals that have shown anti-inflammatory, antiproliferative, antifibrotic, and antiangiogenic activities in different biological systems. This review could be useful to stimulate the evaluation of these phytochemicals as possible therapies for uterine fibroids.
AB - Uterine leiomyomas (fibroids, myomas) are the most common benign tumors of female reproductive tract. They are highly prevalent, with 70-80% of women burdened by the end of their reproductive years. Fibroids are a leading cause of pelvic pain, abnormal vaginal bleeding, pressure on the bladder, miscarriage, and infertility. They are the leading indication for hysterectomy, and costs exceed 6 billion dollars annually in the United States. Unfortunately, no long-term medical treatments are available. Dysregulation of inflammatory processes are thought to be involved in the initiation of leiomyoma and extracellular matrix deposition, cell proliferation, and angiogenesis are the key cellular events implicated in leiomyoma growth. In modern pharmaceutical industries, dietary phytochemicals are used as source of new potential drugs for many kinds of tumors. Dietary phytochemicals may exert therapeutic effects by interfering with key cellular events of the tumorigenesis process. At present, a negligible number of phytochemicals have been tested as therapeutic agents against fibroids. In this context, our aim was to introduce some of the potential dietary phytochemicals that have shown anti-inflammatory, antiproliferative, antifibrotic, and antiangiogenic activities in different biological systems. This review could be useful to stimulate the evaluation of these phytochemicals as possible therapies for uterine fibroids.
KW - Antifibrotic
KW - Antiproliferative
KW - Dietary phytochemicals
KW - Inflammation
KW - Uterine fibroid
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U2 - 10.1002/mnfr.201400134
DO - 10.1002/mnfr.201400134
M3 - Article
C2 - 24976593
AN - SCOPUS:84905404044
SN - 1613-4125
VL - 58
SP - 1667
EP - 1684
JO - Molecular Nutrition and Food Research
JF - Molecular Nutrition and Food Research
IS - 8
ER -