Use of collagen corneal shields versus soft contact lenses to enhance penetration of topical tobramycin

T. P. O'Brien, M. R. Sawusch, J. D. Dick, T. R. Hamburg, John D Gottsch

Research output: Contribution to journalArticle

Abstract

We compared the corneal penetration in rabbits of topical tobramycin in the presence of collagen corneal shields and bandage soft contact lenses. A collagen corneal shield was placed on six albino rabbit eyes, while therapeutic soft contact lenses (61.4% poly-2-hydroxyethyl-methacrylate/38.6% water) were placed on six eyes. Four control eyes received no shield or contact lens. Topical tobramycin was applied to all 16 eyes every five minutes for six doses. Samples of aqueous humor were removed at 15 and 60 minutes following the last dose. Collagen corneal shields allowed a significant (P <.05) increase in tobramycin penetration into the anterior chamber at 60 minutes compared with hydrophilic soft contact lenses or controls.

Original languageEnglish (US)
Pages (from-to)505-507
Number of pages3
JournalJournal of Cataract and Refractive Surgery
Volume14
Issue number5
StatePublished - 1988

Fingerprint

Hydrophilic Contact Lens
Tobramycin
Collagen
Rabbits
Aqueous Humor
Contact Lenses
Anterior Chamber
Bandages
Water

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Use of collagen corneal shields versus soft contact lenses to enhance penetration of topical tobramycin. / O'Brien, T. P.; Sawusch, M. R.; Dick, J. D.; Hamburg, T. R.; Gottsch, John D.

In: Journal of Cataract and Refractive Surgery, Vol. 14, No. 5, 1988, p. 505-507.

Research output: Contribution to journalArticle

O'Brien, T. P. ; Sawusch, M. R. ; Dick, J. D. ; Hamburg, T. R. ; Gottsch, John D. / Use of collagen corneal shields versus soft contact lenses to enhance penetration of topical tobramycin. In: Journal of Cataract and Refractive Surgery. 1988 ; Vol. 14, No. 5. pp. 505-507.
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