Use of collagen corneal shields in the treatment of bacterial keratitis

Mark R. Sawusch, Terrence P. O'Brien, James D. Dick, John D Gottsch

Research output: Contribution to journalArticle

Abstract

We used an animal model of Pseudomonas keratitis to compare treatment by topical tobramycin with and without the presence of a commercially available collagen corneal shield. Pilot studies showed a significant, 30-fold increase in penetration of tobramycin into the anterior chamber in eyes with a collagen shield in place. Twenty albino rabbit eyes were inoculated with P. aeruginosa to produce stromal keratitis. After 12 hours of topical tobramycin dosing, eyes with a collagen corneal shield in place had a statistically significant (P <.01) decrease in colony forming unit counts in comparison to treated eyes without a shield and control eyes.

Original languageEnglish (US)
Pages (from-to)279-281
Number of pages3
JournalAmerican Journal of Ophthalmology
Volume106
Issue number15
DOIs
StatePublished - Sep 15 1988

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Keratitis
Collagen
Tobramycin
Anterior Chamber
Pseudomonas
Stem Cells
Animal Models
Rabbits

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Use of collagen corneal shields in the treatment of bacterial keratitis. / Sawusch, Mark R.; O'Brien, Terrence P.; Dick, James D.; Gottsch, John D.

In: American Journal of Ophthalmology, Vol. 106, No. 15, 15.09.1988, p. 279-281.

Research output: Contribution to journalArticle

Sawusch, Mark R. ; O'Brien, Terrence P. ; Dick, James D. ; Gottsch, John D. / Use of collagen corneal shields in the treatment of bacterial keratitis. In: American Journal of Ophthalmology. 1988 ; Vol. 106, No. 15. pp. 279-281.
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