Abstract
We used an animal model of Pseudomonas keratitis to compare treatment by topical tobramycin with and without the presence of a commercially available collagen corneal shield. Pilot studies showed a significant, 30-fold increase in penetration of tobramycin into the anterior chamber in eyes with a collagen shield in place. Twenty albino rabbit eyes were inoculated with P. aeruginosa to produce stromal keratitis. After 12 hours of topical tobramycin dosing, eyes with a collagen corneal shield in place had a statistically significant (P <.01) decrease in colony forming unit counts in comparison to treated eyes without a shield and control eyes.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 279-281 |
| Number of pages | 3 |
| Journal | American Journal of Ophthalmology |
| Volume | 106 |
| Issue number | 15 |
| DOIs | |
| State | Published - Sep 15 1988 |
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ASJC Scopus subject areas
- Ophthalmology
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Use of collagen corneal shields in the treatment of bacterial keratitis. / Sawusch, Mark R.; O'Brien, Terrence P.; Dick, James D.; Gottsch, John D.
In: American Journal of Ophthalmology, Vol. 106, No. 15, 15.09.1988, p. 279-281.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Use of collagen corneal shields in the treatment of bacterial keratitis
AU - Sawusch, Mark R.
AU - O'Brien, Terrence P.
AU - Dick, James D.
AU - Gottsch, John D
PY - 1988/9/15
Y1 - 1988/9/15
N2 - We used an animal model of Pseudomonas keratitis to compare treatment by topical tobramycin with and without the presence of a commercially available collagen corneal shield. Pilot studies showed a significant, 30-fold increase in penetration of tobramycin into the anterior chamber in eyes with a collagen shield in place. Twenty albino rabbit eyes were inoculated with P. aeruginosa to produce stromal keratitis. After 12 hours of topical tobramycin dosing, eyes with a collagen corneal shield in place had a statistically significant (P <.01) decrease in colony forming unit counts in comparison to treated eyes without a shield and control eyes.
AB - We used an animal model of Pseudomonas keratitis to compare treatment by topical tobramycin with and without the presence of a commercially available collagen corneal shield. Pilot studies showed a significant, 30-fold increase in penetration of tobramycin into the anterior chamber in eyes with a collagen shield in place. Twenty albino rabbit eyes were inoculated with P. aeruginosa to produce stromal keratitis. After 12 hours of topical tobramycin dosing, eyes with a collagen corneal shield in place had a statistically significant (P <.01) decrease in colony forming unit counts in comparison to treated eyes without a shield and control eyes.
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UR - http://www.scopus.com/inward/citedby.url?scp=0023769520&partnerID=8YFLogxK
U2 - 10.1016/0002-9394(88)90361-3
DO - 10.1016/0002-9394(88)90361-3
M3 - Article
VL - 106
SP - 279
EP - 281
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
SN - 0002-9394
IS - 15
ER -