Use of collagen corneal shields in the treatment of bacterial keratitis

Mark R. Sawusch; Terrence P. O'Brien; James D. Dick; John D. Gottsch

doi:10.1016/0002-9394(88)90361-3

Use of collagen corneal shields in the treatment of bacterial keratitis

Mark R. Sawusch, Terrence P. O'Brien, James D. Dick, John D. Gottsch

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

We used an animal model of Pseudomonas keratitis to compare treatment by topical tobramycin with and without the presence of a commercially available collagen corneal shield. Pilot studies showed a significant, 30-fold increase in penetration of tobramycin into the anterior chamber in eyes with a collagen shield in place. Twenty albino rabbit eyes were inoculated with P. aeruginosa to produce stromal keratitis. After 12 hours of topical tobramycin dosing, eyes with a collagen corneal shield in place had a statistically significant (P < .01) decrease in colony forming unit counts in comparison to treated eyes without a shield and control eyes.

Original language	English (US)
Pages (from-to)	279-281
Number of pages	3
Journal	American journal of ophthalmology
Volume	106
Issue number	15
DOIs	https://doi.org/10.1016/0002-9394(88)90361-3
State	Published - Sep 15 1988

ASJC Scopus subject areas

Ophthalmology

Access to Document

10.1016/0002-9394(88)90361-3

Cite this

@article{2adf0cabef4d4501b1dc6664377bc279,

title = "Use of collagen corneal shields in the treatment of bacterial keratitis",

abstract = "We used an animal model of Pseudomonas keratitis to compare treatment by topical tobramycin with and without the presence of a commercially available collagen corneal shield. Pilot studies showed a significant, 30-fold increase in penetration of tobramycin into the anterior chamber in eyes with a collagen shield in place. Twenty albino rabbit eyes were inoculated with P. aeruginosa to produce stromal keratitis. After 12 hours of topical tobramycin dosing, eyes with a collagen corneal shield in place had a statistically significant (P < .01) decrease in colony forming unit counts in comparison to treated eyes without a shield and control eyes.",

author = "Sawusch, {Mark R.} and O'Brien, {Terrence P.} and Dick, {James D.} and Gottsch, {John D.}",

year = "1988",

month = sep,

day = "15",

doi = "10.1016/0002-9394(88)90361-3",

language = "English (US)",

volume = "106",

pages = "279--281",

journal = "American Journal of Ophthalmology",

issn = "0002-9394",

publisher = "Elsevier USA",

number = "15",

}

TY - JOUR

T1 - Use of collagen corneal shields in the treatment of bacterial keratitis

AU - Sawusch, Mark R.

AU - O'Brien, Terrence P.

AU - Dick, James D.

AU - Gottsch, John D.

PY - 1988/9/15

Y1 - 1988/9/15

N2 - We used an animal model of Pseudomonas keratitis to compare treatment by topical tobramycin with and without the presence of a commercially available collagen corneal shield. Pilot studies showed a significant, 30-fold increase in penetration of tobramycin into the anterior chamber in eyes with a collagen shield in place. Twenty albino rabbit eyes were inoculated with P. aeruginosa to produce stromal keratitis. After 12 hours of topical tobramycin dosing, eyes with a collagen corneal shield in place had a statistically significant (P < .01) decrease in colony forming unit counts in comparison to treated eyes without a shield and control eyes.

AB - We used an animal model of Pseudomonas keratitis to compare treatment by topical tobramycin with and without the presence of a commercially available collagen corneal shield. Pilot studies showed a significant, 30-fold increase in penetration of tobramycin into the anterior chamber in eyes with a collagen shield in place. Twenty albino rabbit eyes were inoculated with P. aeruginosa to produce stromal keratitis. After 12 hours of topical tobramycin dosing, eyes with a collagen corneal shield in place had a statistically significant (P < .01) decrease in colony forming unit counts in comparison to treated eyes without a shield and control eyes.

UR - http://www.scopus.com/inward/record.url?scp=0023769520&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023769520&partnerID=8YFLogxK

U2 - 10.1016/0002-9394(88)90361-3

DO - 10.1016/0002-9394(88)90361-3

M3 - Article

C2 - 3138912

AN - SCOPUS:0023769520

VL - 106

SP - 279

EP - 281

JO - American Journal of Ophthalmology

JF - American Journal of Ophthalmology

SN - 0002-9394

IS - 15

ER -

Use of collagen corneal shields in the treatment of bacterial keratitis

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this