Abstract
We used an animal model of Pseudomonas keratitis to compare treatment by topical tobramycin with and without the presence of a commercially available collagen corneal shield. Pilot studies showed a significant, 30-fold increase in penetration of tobramycin into the anterior chamber in eyes with a collagen shield in place. Twenty albino rabbit eyes were inoculated with P. aeruginosa to produce stromal keratitis. After 12 hours of topical tobramycin dosing, eyes with a collagen corneal shield in place had a statistically significant (P < .01) decrease in colony forming unit counts in comparison to treated eyes without a shield and control eyes.
Original language | English (US) |
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Pages (from-to) | 279-281 |
Number of pages | 3 |
Journal | American journal of ophthalmology |
Volume | 106 |
Issue number | 15 |
DOIs | |
State | Published - Sep 15 1988 |
ASJC Scopus subject areas
- Ophthalmology