Use of cidofovir with extracorporeal membrane oxygenation to treat adenovirus-associated acute respiratory distress syndrome in paediatric patients— a case series

Thao K. Le, Brian K. Brown, Katie C. Namtu, David M. Berman, Amy L. Kiskaddon

Research output: Contribution to journalArticlepeer-review

Abstract

What is known and objective: Reports of cidofovir dosing with extracorporeal membrane oxygenation (ECMO) support are limited. This case series describes our clinical experience and provides a literature review regarding cidofovir dosing in paediatric patients requiring ECMO support. Case summary: Three patients with adenovirus-associated acute respiratory distress syndrome (ARDS) were treated with cidofovir while requiring ECMO support. A 27-month-old patient was treated with cidofovir 1 mg/kg/dose three times weekly, and a 19-month-old patient and an 18-year-old patient were treated with cidofovir 5 mg/kg/dose weekly. What is new and conclusion: This case series describes the dosing and positive clinical response of cidofovir in paediatric patients with adenovirus-associated ARDS requiring ECMO support.

Original languageEnglish (US)
Pages (from-to)1505-1510
Number of pages6
JournalJournal of Clinical Pharmacy and Therapeutics
Volume45
Issue number6
DOIs
StatePublished - Dec 1 2020
Externally publishedYes

Keywords

  • acute respiratory distress syndrome
  • dosing regimen
  • paediatrics
  • pharmacokinetics

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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