Use of buprenorphine in the treatment of opioid addiction. II. Physiologic and behavioral effects of daily and alternate-day administration and abrupt withdrawal

Paul J. Fudala, Jerome H. Jaffe, Elizabeth M. Dax, Rolley E. Johnson

Research output: Contribution to journalArticle

Abstract

Nineteen heroin-dependent mate volunteers were administered buprenorphine sublingually, in ascending daily doses of 2, 4, and 8 mg. They were maintained on 8 mg daily through study day 18. On study days 19 through 36, subjects in group 1 continued to receive burprenorphine daily; subjects in group 2 received buprenorphine or placebo on alternate days. On days 37 through 52, all subjects received placebo. Subjects receiving buprenorphine on alternate days reported significantly greater urge for an opioid, increased dysphoria scores, and pupillary dilation on placebo days. After abrupt termination of buprenorphine, no withdrawal signs were detected with the H mmelsbach scale. However, subjects reported mild-to-moderate opioid withdrawal symptoms; peaking at 3 to 5 and lasting for 8 to 10 days. Daily administration of buprenorphine provided greater control of subtle opioid withdrawal symptoms, but subjects could tolerate a between-dose interval of 48 hours.

Original languageEnglish (US)
Pages (from-to)525-534
Number of pages10
JournalClinical Pharmacology and Therapeutics
Volume47
Issue number4
StatePublished - Apr 1990

ASJC Scopus subject areas

  • Pharmacology

Fingerprint Dive into the research topics of 'Use of buprenorphine in the treatment of opioid addiction. II. Physiologic and behavioral effects of daily and alternate-day administration and abrupt withdrawal'. Together they form a unique fingerprint.

  • Cite this