USE OF ANTISERA FOR IDENTIFICATION OF ENTEROTOXIGENIC ESCHERICHIA COLI

Michael H. Merson; Robert E. Black; Roger J. Gross; Bernard Rowe; Imadul Huq; Abu Eusof

doi:10.1016/S0140-6736(80)90118-X

USE OF ANTISERA FOR IDENTIFICATION OF ENTEROTOXIGENIC ESCHERICHIA COLI

Michael H. Merson, Robert E. Black, Roger J. Gross, Bernard Rowe, Imadul Huq, Abu Eusof

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

The usual methods for identifying enterotoxigenic Escherichia coli (ETEC) strains involve testing for production of heat-labile and heat-stable enterotoxins. To simplify the identification of ETEC, antisera against common ETEC O serogroups were used to identify ETEC in the stools from 618 patients with acute diarrhœa and dehydration (≽5% loss of body-weight) receiving treatment at a hospital in Dacca, Bangladesh. Compared with enterotoxin testing the antisera had a sensitivity of 64%, a specificity of 96%, and a predictive accuracy of 89%. These antisera may be useful in the identification ETEC in clinical laboratories which are unable to perform toxin testing and should be evaluated in other geographical areas.

Original language	English (US)
Pages (from-to)	222-224
Number of pages	3
Journal	The Lancet
Volume	316
Issue number	8188
DOIs	https://doi.org/10.1016/S0140-6736(80)90118-X
State	Published - 1980
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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title = "USE OF ANTISERA FOR IDENTIFICATION OF ENTEROTOXIGENIC ESCHERICHIA COLI",

abstract = "The usual methods for identifying enterotoxigenic Escherichia coli (ETEC) strains involve testing for production of heat-labile and heat-stable enterotoxins. To simplify the identification of ETEC, antisera against common ETEC O serogroups were used to identify ETEC in the stools from 618 patients with acute diarrh{\oe}a and dehydration (≽5% loss of body-weight) receiving treatment at a hospital in Dacca, Bangladesh. Compared with enterotoxin testing the antisera had a sensitivity of 64%, a specificity of 96%, and a predictive accuracy of 89%. These antisera may be useful in the identification ETEC in clinical laboratories which are unable to perform toxin testing and should be evaluated in other geographical areas.",

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AU - Merson, Michael H.

AU - Black, Robert E.

AU - Gross, Roger J.

AU - Rowe, Bernard

AU - Huq, Imadul

AU - Eusof, Abu

PY - 1980

Y1 - 1980

N2 - The usual methods for identifying enterotoxigenic Escherichia coli (ETEC) strains involve testing for production of heat-labile and heat-stable enterotoxins. To simplify the identification of ETEC, antisera against common ETEC O serogroups were used to identify ETEC in the stools from 618 patients with acute diarrhœa and dehydration (≽5% loss of body-weight) receiving treatment at a hospital in Dacca, Bangladesh. Compared with enterotoxin testing the antisera had a sensitivity of 64%, a specificity of 96%, and a predictive accuracy of 89%. These antisera may be useful in the identification ETEC in clinical laboratories which are unable to perform toxin testing and should be evaluated in other geographical areas.

AB - The usual methods for identifying enterotoxigenic Escherichia coli (ETEC) strains involve testing for production of heat-labile and heat-stable enterotoxins. To simplify the identification of ETEC, antisera against common ETEC O serogroups were used to identify ETEC in the stools from 618 patients with acute diarrhœa and dehydration (≽5% loss of body-weight) receiving treatment at a hospital in Dacca, Bangladesh. Compared with enterotoxin testing the antisera had a sensitivity of 64%, a specificity of 96%, and a predictive accuracy of 89%. These antisera may be useful in the identification ETEC in clinical laboratories which are unable to perform toxin testing and should be evaluated in other geographical areas.

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USE OF ANTISERA FOR IDENTIFICATION OF ENTEROTOXIGENIC ESCHERICHIA COLI

Abstract

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