Use of Antiretroviral Drugs to Prevent HIV-1 Transmission Through Breast-feeding: From Animal Studies to Randomized Clinical Trials

Philippe Gaillard, Mary Glenn Fowler, Francois Dabis, Hoosen Coovadia, Charles Van Der Horst, Koen Van Rompay, Andrea Ruff, Taha Taha, Tim Thomas, Isabelle De Vincenzi, Marie Louise Newell

Research output: Contribution to journalArticle

Abstract

The major remaining challenge in the prevention of mother-to-child transmission is the reduction of the risk in settings where breast-feeding is common. This review gives an update on ongoing or planned antiretroviral intervention studies in resource-limited settings that are aimed at reducing the risk of mother-to-infant HIV transmission during lactation. These strategies include antiretroviral therapy given to the mother to reduce viral load in plasma and breast milk as well as antiretroviral regimens providing prophylaxis to uninfected infants during the period of breast-feeding. The rationale for the interventions based on animal models and human studies is described as well as the study designs of clinical trials. Potential risks and benefits of these interventions to mothers and infants are also highlighted. Laboratory studies nested within several of these trials will provide a better understanding of the pathogenesis of postnatal HIV transmission and its potential prevention using antiretroviral drugs.

Original languageEnglish (US)
Pages (from-to)178-187
Number of pages10
JournalJournal of Acquired Immune Deficiency Syndromes
Volume35
Issue number2
DOIs
StatePublished - Feb 1 2004

Fingerprint

Breast Feeding
HIV-1
Randomized Controlled Trials
Mothers
Pharmaceutical Preparations
HIV
Human Milk
Risk Reduction Behavior
Viral Load
Lactation
Animal Models
Clinical Trials
Therapeutics

Keywords

  • Antiretroviral drugs
  • Prevention
  • Transmission through breastfeeding

ASJC Scopus subject areas

  • Virology
  • Immunology

Cite this

Use of Antiretroviral Drugs to Prevent HIV-1 Transmission Through Breast-feeding : From Animal Studies to Randomized Clinical Trials. / Gaillard, Philippe; Fowler, Mary Glenn; Dabis, Francois; Coovadia, Hoosen; Van Der Horst, Charles; Van Rompay, Koen; Ruff, Andrea; Taha, Taha; Thomas, Tim; De Vincenzi, Isabelle; Newell, Marie Louise.

In: Journal of Acquired Immune Deficiency Syndromes, Vol. 35, No. 2, 01.02.2004, p. 178-187.

Research output: Contribution to journalArticle

Gaillard, Philippe ; Fowler, Mary Glenn ; Dabis, Francois ; Coovadia, Hoosen ; Van Der Horst, Charles ; Van Rompay, Koen ; Ruff, Andrea ; Taha, Taha ; Thomas, Tim ; De Vincenzi, Isabelle ; Newell, Marie Louise. / Use of Antiretroviral Drugs to Prevent HIV-1 Transmission Through Breast-feeding : From Animal Studies to Randomized Clinical Trials. In: Journal of Acquired Immune Deficiency Syndromes. 2004 ; Vol. 35, No. 2. pp. 178-187.
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