TY - JOUR
T1 - Use of Antiretroviral Drugs to Prevent HIV-1 Transmission Through Breast-feeding
T2 - From Animal Studies to Randomized Clinical Trials
AU - Gaillard, Philippe
AU - Fowler, Mary Glenn
AU - Dabis, Francois
AU - Coovadia, Hoosen
AU - Van Der Horst, Charles
AU - Van Rompay, Koen
AU - Ruff, Andrea
AU - Taha, Taha
AU - Thomas, Tim
AU - De Vincenzi, Isabelle
AU - Newell, Marie Louise
PY - 2004/2/1
Y1 - 2004/2/1
N2 - The major remaining challenge in the prevention of mother-to-child transmission is the reduction of the risk in settings where breast-feeding is common. This review gives an update on ongoing or planned antiretroviral intervention studies in resource-limited settings that are aimed at reducing the risk of mother-to-infant HIV transmission during lactation. These strategies include antiretroviral therapy given to the mother to reduce viral load in plasma and breast milk as well as antiretroviral regimens providing prophylaxis to uninfected infants during the period of breast-feeding. The rationale for the interventions based on animal models and human studies is described as well as the study designs of clinical trials. Potential risks and benefits of these interventions to mothers and infants are also highlighted. Laboratory studies nested within several of these trials will provide a better understanding of the pathogenesis of postnatal HIV transmission and its potential prevention using antiretroviral drugs.
AB - The major remaining challenge in the prevention of mother-to-child transmission is the reduction of the risk in settings where breast-feeding is common. This review gives an update on ongoing or planned antiretroviral intervention studies in resource-limited settings that are aimed at reducing the risk of mother-to-infant HIV transmission during lactation. These strategies include antiretroviral therapy given to the mother to reduce viral load in plasma and breast milk as well as antiretroviral regimens providing prophylaxis to uninfected infants during the period of breast-feeding. The rationale for the interventions based on animal models and human studies is described as well as the study designs of clinical trials. Potential risks and benefits of these interventions to mothers and infants are also highlighted. Laboratory studies nested within several of these trials will provide a better understanding of the pathogenesis of postnatal HIV transmission and its potential prevention using antiretroviral drugs.
KW - Antiretroviral drugs
KW - Prevention
KW - Transmission through breastfeeding
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U2 - 10.1097/00126334-200402010-00013
DO - 10.1097/00126334-200402010-00013
M3 - Review article
C2 - 14722452
AN - SCOPUS:9144253114
SN - 1525-4135
VL - 35
SP - 178
EP - 187
JO - Journal of Acquired Immune Deficiency Syndromes
JF - Journal of Acquired Immune Deficiency Syndromes
IS - 2
ER -