Use of androgen deprivation therapy in prostate cancer: Indications and prevalence

Research output: Contribution to journalArticle

Abstract

Androgens play a prominent role in the development, maintenance and progression of prostate cancer. The introduction of androgen deprivation therapies into the treatment paradigm for prostate cancer patients has resulted in a wide variety of benefits ranging from a survival advantage for those with clinically localized or locally advanced disease, to improvements in symptom control for patients with advanced disease. Controversies remain, however, surrounding the optimal timing, duration and schedule of these hormonal approaches. Newer hormonal manipulations such as abiraterone acetate have also been investigated and will broaden treatment options for men with prostate cancer. This review highlights the various androgen-directed treatment options available to men with prostate cancer, their specific indications and the evidence supporting each approach, as well as patterns of use of hormonal therapies.

Original languageEnglish (US)
Pages (from-to)177-186
Number of pages10
JournalAsian Journal of Andrology
Volume14
Issue number2
DOIs
StatePublished - Mar 2012

Fingerprint

Androgens
Prostatic Neoplasms
Therapeutics
Appointments and Schedules
Maintenance
Survival

Keywords

  • androgen deprivation therapy
  • androgen synthesis
  • anti-androgen
  • prostate cancer

ASJC Scopus subject areas

  • Urology

Cite this

Use of androgen deprivation therapy in prostate cancer : Indications and prevalence. / Connolly, Roisin; Carducci, Michael A; Antonarakis, Emmanuel.

In: Asian Journal of Andrology, Vol. 14, No. 2, 03.2012, p. 177-186.

Research output: Contribution to journalArticle

@article{ab1d468142554744a0ee5cb3b3898837,
title = "Use of androgen deprivation therapy in prostate cancer: Indications and prevalence",
abstract = "Androgens play a prominent role in the development, maintenance and progression of prostate cancer. The introduction of androgen deprivation therapies into the treatment paradigm for prostate cancer patients has resulted in a wide variety of benefits ranging from a survival advantage for those with clinically localized or locally advanced disease, to improvements in symptom control for patients with advanced disease. Controversies remain, however, surrounding the optimal timing, duration and schedule of these hormonal approaches. Newer hormonal manipulations such as abiraterone acetate have also been investigated and will broaden treatment options for men with prostate cancer. This review highlights the various androgen-directed treatment options available to men with prostate cancer, their specific indications and the evidence supporting each approach, as well as patterns of use of hormonal therapies.",
keywords = "androgen deprivation therapy, androgen synthesis, anti-androgen, prostate cancer",
author = "Roisin Connolly and Carducci, {Michael A} and Emmanuel Antonarakis",
year = "2012",
month = "3",
doi = "10.1038/aja.2011.103",
language = "English (US)",
volume = "14",
pages = "177--186",
journal = "Asian Journal of Andrology",
issn = "1008-682X",
publisher = "Nature Publishing Group",
number = "2",

}

TY - JOUR

T1 - Use of androgen deprivation therapy in prostate cancer

T2 - Indications and prevalence

AU - Connolly, Roisin

AU - Carducci, Michael A

AU - Antonarakis, Emmanuel

PY - 2012/3

Y1 - 2012/3

N2 - Androgens play a prominent role in the development, maintenance and progression of prostate cancer. The introduction of androgen deprivation therapies into the treatment paradigm for prostate cancer patients has resulted in a wide variety of benefits ranging from a survival advantage for those with clinically localized or locally advanced disease, to improvements in symptom control for patients with advanced disease. Controversies remain, however, surrounding the optimal timing, duration and schedule of these hormonal approaches. Newer hormonal manipulations such as abiraterone acetate have also been investigated and will broaden treatment options for men with prostate cancer. This review highlights the various androgen-directed treatment options available to men with prostate cancer, their specific indications and the evidence supporting each approach, as well as patterns of use of hormonal therapies.

AB - Androgens play a prominent role in the development, maintenance and progression of prostate cancer. The introduction of androgen deprivation therapies into the treatment paradigm for prostate cancer patients has resulted in a wide variety of benefits ranging from a survival advantage for those with clinically localized or locally advanced disease, to improvements in symptom control for patients with advanced disease. Controversies remain, however, surrounding the optimal timing, duration and schedule of these hormonal approaches. Newer hormonal manipulations such as abiraterone acetate have also been investigated and will broaden treatment options for men with prostate cancer. This review highlights the various androgen-directed treatment options available to men with prostate cancer, their specific indications and the evidence supporting each approach, as well as patterns of use of hormonal therapies.

KW - androgen deprivation therapy

KW - androgen synthesis

KW - anti-androgen

KW - prostate cancer

UR - http://www.scopus.com/inward/record.url?scp=84858045491&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84858045491&partnerID=8YFLogxK

U2 - 10.1038/aja.2011.103

DO - 10.1038/aja.2011.103

M3 - Article

C2 - 22231299

AN - SCOPUS:84858045491

VL - 14

SP - 177

EP - 186

JO - Asian Journal of Andrology

JF - Asian Journal of Andrology

SN - 1008-682X

IS - 2

ER -