Use of androgen deprivation therapy in prostate cancer: Indications and prevalence

Research output: Contribution to journalReview articlepeer-review

Abstract

Androgens play a prominent role in the development, maintenance and progression of prostate cancer. The introduction of androgen deprivation therapies into the treatment paradigm for prostate cancer patients has resulted in a wide variety of benefits ranging from a survival advantage for those with clinically localized or locally advanced disease, to improvements in symptom control for patients with advanced disease. Controversies remain, however, surrounding the optimal timing, duration and schedule of these hormonal approaches. Newer hormonal manipulations such as abiraterone acetate have also been investigated and will broaden treatment options for men with prostate cancer. This review highlights the various androgen-directed treatment options available to men with prostate cancer, their specific indications and the evidence supporting each approach, as well as patterns of use of hormonal therapies.

Original languageEnglish (US)
Pages (from-to)177-186
Number of pages10
JournalAsian Journal of Andrology
Volume14
Issue number2
DOIs
StatePublished - Mar 2012

Keywords

  • androgen deprivation therapy
  • androgen synthesis
  • anti-androgen
  • prostate cancer

ASJC Scopus subject areas

  • Urology

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