Use of acousto-optic tuneable filter in fluorescence imaging endoscopy

Mounir Bouhifd, Maurice Whelan, Marc Aprahamian

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A prototype instrument for fluorescence-based medical diagnostics in vivo is described. The system consists of a rigid endoscope comprising a UV laser-source for fluorescence excitation and a white light source for direct imaging. An acousto-optic tuneable filter (AOTF) is employed as a full-field tuneable bandpass filter. This allows fast continuous or random-access tuning with high filtering efficiency. A study of the diagnostic potential of fluorescence imaging for pancreatitis was conducted on a rat model. In particular, the aim was to detect autofluorescence of endogenous protoporphyrin IX (PpIX) that has been shown to accumulate in early-stage diseased tissue undergoing an inflammatory response.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsA.-C. Boccara
Pages305-314
Number of pages10
Volume5143
StatePublished - 2003
Externally publishedYes
EventNovel Optical Instrumentation for Biomedical Applications - Munich, Germany
Duration: Jun 24 2003Jun 25 2003

Other

OtherNovel Optical Instrumentation for Biomedical Applications
CountryGermany
CityMunich
Period6/24/036/25/03

Fingerprint

Endoscopy
acousto-optics
Optics
Fluorescence
Imaging techniques
filters
fluorescence
Light sources
random access
endoscopes
Bandpass filters
bandpass filters
ultraviolet lasers
rats
Rats
light sources
Tuning
tuning
prototypes
Tissue

Keywords

  • AOTF filtering
  • Endogenous protoporphyrin IX
  • Endoscope
  • Fluorescence imaging

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Bouhifd, M., Whelan, M., & Aprahamian, M. (2003). Use of acousto-optic tuneable filter in fluorescence imaging endoscopy. In A-C. Boccara (Ed.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 5143, pp. 305-314)

Use of acousto-optic tuneable filter in fluorescence imaging endoscopy. / Bouhifd, Mounir; Whelan, Maurice; Aprahamian, Marc.

Proceedings of SPIE - The International Society for Optical Engineering. ed. / A.-C. Boccara. Vol. 5143 2003. p. 305-314.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Bouhifd, M, Whelan, M & Aprahamian, M 2003, Use of acousto-optic tuneable filter in fluorescence imaging endoscopy. in A-C Boccara (ed.), Proceedings of SPIE - The International Society for Optical Engineering. vol. 5143, pp. 305-314, Novel Optical Instrumentation for Biomedical Applications, Munich, Germany, 6/24/03.
Bouhifd M, Whelan M, Aprahamian M. Use of acousto-optic tuneable filter in fluorescence imaging endoscopy. In Boccara A-C, editor, Proceedings of SPIE - The International Society for Optical Engineering. Vol. 5143. 2003. p. 305-314
Bouhifd, Mounir ; Whelan, Maurice ; Aprahamian, Marc. / Use of acousto-optic tuneable filter in fluorescence imaging endoscopy. Proceedings of SPIE - The International Society for Optical Engineering. editor / A.-C. Boccara. Vol. 5143 2003. pp. 305-314
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