Use of a voxelwise approach in the analysis of fractional anisotropy data in multiple sclerosis patients

Sunil A. Patel, Barbara Hum, Carlos F. Gonzalez, Robert Schwartzman, Scott H. Faro, Feroze B. Mohamed

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Diffusion tensor magnetic resonance imaging (DTI) has the ability to provide non-invasive information on tissue microstructure not available in routine clinical MRI images. This includes information regarding the degree of anisotropy as well as the direction of the diffusion of water molecules within the tissues. Since white matter areas of the brain have an ordered structure (due to the myelination and directionality of axons) and thus a high degree of anisotropy, the ability to detect changes in anisotropy can be extremely useful in the study of diseases such as multiple sclerosis (MS), which involves the demyelination of axons. Several studies have used DTI to investigate well defined MS lesions as well as normal appearing white matter (NAWM) lesions not seen in conventional MR images. These studies have typically used region of interest (ROI) based approaches to analyze the data. However, studies using ROI based analysis techniques have several drawbacks. These include the time required to draw ROIs, the reproducibility of these ROIs, and the accuracy of placement of these ROIs, especially in NAWM regions where there is no a priori knowledge of the presence or absence of MS lesions. In this study, we have demonstrated the utilization of a semi-automated method for performing a voxelwise analysis in the detection of MS lesions.

Original languageEnglish (US)
Title of host publicationProceedings of the 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005
Pages7032-7035
Number of pages4
StatePublished - Dec 1 2005
Event2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005 - Shanghai, China
Duration: Sep 1 2005Sep 4 2005

Publication series

NameAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume7 VOLS
ISSN (Print)0589-1019

Other

Other2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005
CountryChina
CityShanghai
Period9/1/059/4/05

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ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

Cite this

Patel, S. A., Hum, B., Gonzalez, C. F., Schwartzman, R., Faro, S. H., & Mohamed, F. B. (2005). Use of a voxelwise approach in the analysis of fractional anisotropy data in multiple sclerosis patients. In Proceedings of the 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005 (pp. 7032-7035). [1616125] (Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings; Vol. 7 VOLS).