Use of a modified chitosan dressing in a hypothermic Coagulopathic grade V liver injury model

Grant Bochicchio, Michael Kilbourne, Reed Kuehn, Kaspar Keledjian, John Hess, Thomas Scalea

Research output: Contribution to journalArticle

Abstract

Background: Exsanguination from hepatic trauma is exacerbated by the lethal triad of acidosis, coagulopathy, and hypothermia. We evaluated the application of a modified chitosan dressing in a hypothermic coagulopathic model of grade V liver injury. Methods: Subject swine underwent induced hypothermic coagulopathy followed by standardized grade V liver injuries. A modified chitosan dressing was applied and compared with standard packing. Results: Pretreatment temperature, activated clotting time, and blood loss were similar between groups. Post treatment blood loss was significantly less and resuscitation mean arterial pressure were significantly greater in the modified chitosan group (P <.0001 and P <.018, respectively). Mean fluid resuscitative volume was significantly less in the modified chitosan group (P <.0056). Hemostasis was achieved on average 5.2 minutes following modified chitosan and never achieved with standard packing. At 1 hour post injury, all treatment animals survived compared with half of controls. Conclusions: Modified chitosan dressings provide simple rapid treatment of life-threatening liver injuries.

Original languageEnglish (US)
Pages (from-to)617-622
Number of pages6
JournalAmerican Journal of Surgery
Volume198
Issue number5
DOIs
StatePublished - Nov 2009
Externally publishedYes

Keywords

  • Advance hemostasis
  • Chitosan
  • Hemorrhage

ASJC Scopus subject areas

  • Surgery

Fingerprint Dive into the research topics of 'Use of a modified chitosan dressing in a hypothermic Coagulopathic grade V liver injury model'. Together they form a unique fingerprint.

  • Cite this