Use of a clinicoradiological score to determine the presurgical diagnosis of autoimmune hypophysitis in a teenage girl

Vivek Bose, Patrizio Caturegli, Jens Conrad, Wael Omran, Steph An Boor, Alf Giese, Angelika Gutenberg

Research output: Contribution to journalArticlepeer-review

Abstract

difficult to determine with certainty without pituitary biopsy and pathological examination. To aid in this distinction, the authors recently published a clinicoradiological scoring system, which they used in the case of a 15-year-old girl presented here. The patient presented with headache, visual field defects, polydipsia, and polyuria, and she was found to have secondary hypogonadism and hypoadrenalism. Magnetic resonance imaging showed a pituitary mass of approximately 2 cm in diameter. Application of the clinicoradiological parameters gave a score of 6, which favored a diagnosis of hypophysitis over that of adenoma. The presence of pituitary autoantibodies substantiated the diagnosis of hypophysitis. The patient was treated conservatively with high-dose prednisolone, and her symptoms improved markedly. This case illustrates the utility of using a clinicoradiological score when autoimmune hypophysitis is suspected since it can identify patients who can be treated without the need for pituitary surgery.

Original languageEnglish (US)
Pages (from-to)335-339
Number of pages5
JournalJournal of Neurosurgery: Pediatrics
Volume11
Issue number3
DOIs
StatePublished - Mar 2013

Keywords

  • Hypophysitis
  • Pituitary antibody
  • Pituitary surgery
  • Radiological score

ASJC Scopus subject areas

  • Surgery
  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

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