Abstract
USA300 methicillin-resistant Staphylococcus aureus (MRSA) is increasing as a cause of severe community-associated bacteremic infections. We assessed severe sepsis in response to infection in patients with USA300 MRSA compared to non-USA300 MRSA bacteremia. A cohort study was conducted from 1997 to 2008 comparing sepsis in response to infection in 271 patients with MRSA bacteremia from 4 VA hospitals. Sixty-seven (25%) patients with MRSA bacteremia were USA300 MRSA; 204 (75%) were non-USA300 MRSA. The proportion of MRSA bacteremia caused by USA300 MRSA increased over time (X2 P <0.0001). Adjusting for age and nosocomial infection, patients with USA300 MRSA bacteremia were more likely to have severe sepsis or septic shock in response to infection than patients with non-USA300 MRSA bacteremia (adjusted relative risk = 1.82; 95% confidence interval, 1.16-2.87; P = 0.01). This suggests that patients with USA300 MRSA are more likely to develop severe sepsis in response to their infection, which could be due to host or bacterial differences.
Original language | English (US) |
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Pages (from-to) | 285-290 |
Number of pages | 6 |
Journal | Diagnostic Microbiology and Infectious Disease |
Volume | 70 |
Issue number | 3 |
DOIs | |
State | Published - Jul 2011 |
Externally published | Yes |
Keywords
- Bacteremia
- Bacterial typing techniques
- Community-acquired infections
- Electrophoresis
- Gel
- Methicillin resistance
- Pulsed-field
- Staphylococcus aureus
ASJC Scopus subject areas
- Microbiology (medical)
- Infectious Diseases