USA300 methicillin-resistant Staphylococcus aureus bacteremia and the risk of severe sepsis: Is USA300 methicillin-resistant Staphylococcus aureus associated with more severe infections?

Kristen M. Kreisel, O. Colin Stine, J. Kristie Johnson, Eli N. Perencevich, Michelle D. Shardell, Alan J. Lesse, Fred M. Gordin, Michael W. Climo, Mary Claire Roghmann

Research output: Contribution to journalArticlepeer-review

Abstract

USA300 methicillin-resistant Staphylococcus aureus (MRSA) is increasing as a cause of severe community-associated bacteremic infections. We assessed severe sepsis in response to infection in patients with USA300 MRSA compared to non-USA300 MRSA bacteremia. A cohort study was conducted from 1997 to 2008 comparing sepsis in response to infection in 271 patients with MRSA bacteremia from 4 VA hospitals. Sixty-seven (25%) patients with MRSA bacteremia were USA300 MRSA; 204 (75%) were non-USA300 MRSA. The proportion of MRSA bacteremia caused by USA300 MRSA increased over time (X2 P <0.0001). Adjusting for age and nosocomial infection, patients with USA300 MRSA bacteremia were more likely to have severe sepsis or septic shock in response to infection than patients with non-USA300 MRSA bacteremia (adjusted relative risk = 1.82; 95% confidence interval, 1.16-2.87; P = 0.01). This suggests that patients with USA300 MRSA are more likely to develop severe sepsis in response to their infection, which could be due to host or bacterial differences.

Original languageEnglish (US)
Pages (from-to)285-290
Number of pages6
JournalDiagnostic Microbiology and Infectious Disease
Volume70
Issue number3
DOIs
StatePublished - Jul 2011
Externally publishedYes

Keywords

  • Bacteremia
  • Bacterial typing techniques
  • Community-acquired infections
  • Electrophoresis
  • Gel
  • Methicillin resistance
  • Pulsed-field
  • Staphylococcus aureus

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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