US wingspan registry: 12-month follow-up results

David J. Fiorella, Aquilla S. Turk, Elad I. Levy, G. Lee Pride, Henry H. Woo, Felipe C. Albuquerque, Babu G. Welch, David B. Niemann, Beverly Aagaard-Kienitz, Peter A. Rasmussen, L. Nelson Hopkins, Thomas J. Masaryk, Cameron McDougall

Research output: Contribution to journalArticle

Abstract

Background and Purpose- The purpose of this study is to present 12-month follow-up results for a series of patients undergoing percutaneous transluminal angioplasty and stenting with the Gateway-Wingspan stenting system (Boston Scientific) for the treatment of symptomatic intracranial atherostenosis. Methods- Clinical and angiographic follow-up results were recorded for patients from 5 participating institutions. Primary end points were stroke or death within 30 days of the stenting procedure or ipsilateral stroke after 30 days. Results- During a 21-month study period, 158 patients with 168 intracranial atherostenotic lesions (50% to 99%) were treated with the Gateway-Wingspan system. The average follow-up duration was 14.2 months with 143 patients having at least 3 months of clinical follow-up and 110 having at least 12 months. The cumulative rate of the primary end point was 15.7% for all patients and 13.9% for patients with high-grade (70% to 99%) stenosis. Of 13 ipsilateral strokes occurring after 30 days, 3 resulted in death. Of these strokes, 76.9% (10 of 13) occurred within the first 6 months of the stenting procedure and no events were recorded after 12 months. An additional 9 patients experienced ipsilateral transient ischemic attack after 30 days. Most postprocedural events (86%) could be attributed to interruption of antiplatelet medications (n=6), in-stent restenosis (n=12), or both (n=1). In 3 patients, the events were of uncertain etiology. Conclusions- After successful Wingspan percutaneous transluminal angioplasty and stenting, some patients continued to experience ipsilateral ischemic events. Most of these ischemic events occurred within 6 months of the procedure and were associated with the interruption of antiplatelet therapy or in-stent restenosis.

Original languageEnglish (US)
Pages (from-to)1976-1981
Number of pages6
JournalStroke
Volume42
Issue number7
DOIs
Publication statusPublished - Jul 1 2011
Externally publishedYes

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Keywords

  • angioplasty
  • intracranial atheromatous disease
  • stenting
  • symptomatic intracranial stenosis
  • Wingspan

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Advanced and Specialized Nursing
  • Medicine(all)

Cite this

Fiorella, D. J., Turk, A. S., Levy, E. I., Pride, G. L., Woo, H. H., Albuquerque, F. C., ... McDougall, C. (2011). US wingspan registry: 12-month follow-up results. Stroke, 42(7), 1976-1981. https://doi.org/10.1161/STROKEAHA.111.613877