US practitioner prescribing practices and patient characteristics of those newly treated with a buprenorphine transdermal patch system

Joseph V. Pergolizzi, Rami Ben-Joseph, Chun Lan Chang, Gregory Hess

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: Medication prescribing information provides guidance to healthcare providers on how to prescribe a drug properly. Oftentimes patient factors in addition to the prescribing information are considered when selecting medications. Utilizing real-world pharmacy and medical claims data, this study assessed US practitioner prescribing practices of US approved transdermal buprenorphine system (BTDS) in relation to BTDS's full prescribing information (FPI) as well as the relationship between patient factors and initial BTDS dose. Research design and methods: Patients aged ≥18 years initiating BTDS between 1 January 2011 and 30 November 2011 were identified in the IMS Pharmacy and Private Practitioner Medical Claims databases. The index date was defined as the first filled BTDS prescription. Demographics, chronic pain-related medical conditions in the 12 months pre-index and prior medication use in the 6 months pre-index were assessed. Initial BTDS dosing strength, receipt of approved initial BTDS dose per the FPI, and concomitant medications were assessed in the post-index 6 month period. Results: The study included 10,457 patients newly treated with BTDS. The majority of patients were female (69.9%) with a mean (±SD) age of 54.5 (±15.2) years. Within the 6 months prior to the index BTDS prescription, 91.7% of the patients used opioids. Overall, 48.9% of patients were prescribed the FPI approved BTDS dose. When stratified, 73.5% of opioid-naïve patients received the FPI approved initial dose compared to 46.0% of those with prior opioid experience of ≤80mg morphine-equivalent daily dose. Patients on BTDS alone (i.e. monotherapy) had a higher rate of receiving the FPI approved initial BTDS dose compared to patients on BTDS concomitant regimens (p

Original languageEnglish (US)
Pages (from-to)1579-1587
Number of pages9
JournalCurrent Medical Research and Opinion
Volume30
Issue number8
DOIs
StatePublished - 2014

Keywords

  • Opioid
  • Opioid experience
  • Opioid-naïve
  • Prescription claims
  • Transdermal buprenorphine

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint

Dive into the research topics of 'US practitioner prescribing practices and patient characteristics of those newly treated with a buprenorphine transdermal patch system'. Together they form a unique fingerprint.

Cite this